'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective
文献类型：期刊论文
| 作者 | Fu, Liyi2,3,4; Zhang, Yang2,3; Farokhzad, Ryan A.2,3; Mendes, Barbara B.1; Conde, Joao1; Shi, Jinjun2,3 |
| 刊名 | CHEMICAL SOCIETY REVIEWS
 |
| 出版日期 | 2023-10-11 |
| ISSN号 | 0306-0012 |
| DOI | 10.1039/d2cs00998 |
| 通讯作者 | Shi, Jinjun() |
| 英文摘要 | Nanotechnology has shown tremendous success in the drug delivery field for more effective and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new class of therapeutics. Various nanoparticle strategies have been developed to improve the systemic delivery of therapeutics, among which surface modification of targeting ligands on nanoparticles has been widely explored for 'active' delivery to a specific organ or diseased tissue. Meanwhile, compelling evidence has recently been reported that organ-selective targeting may also be achievable by systemic administration of nanoparticles without surface ligand modification. In this Review, we highlight this unique set of 'passive' nanoparticles and their compositions and mechanisms for organ-selective delivery. In particular, the lipid-based, polymer-based, and biomimetic nanoparticles with tropism to different specific organs after intravenous administration are summarized. The underlying mechanisms (e.g., protein corona and size effect) of these nanosystems for organ selectivity are also extensively discussed. We further provide perspectives on the opportunities and challenges in this exciting area of organ-selective systemic nanoparticle delivery. This review article highlights a unique set of 'passive' nanoparticles for organ-selective systemic delivery and discusses the underlying biological mechanisms. |
| WOS关键词 | MESSENGER-RNA DELIVERY ; PROTEIN CORONA ; LIPID NANOPARTICLES ; TARGETED DELIVERY ; DRUG-DELIVERY ; MESOSCALE NANOPARTICLES ; LUNG ENDOTHELIUM ; SIRNA DELIVERY ; LIVER ; ADSORPTION |
| 资助项目 | J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01CA200900] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL156362] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL158097] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL159012] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL162367] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R33HL168751] ; National Institutes of Health[848325] ; European Research Council - ERC |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001078874400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th ; National Institutes of Health ; European Research Council - ERC |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/133435]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Shi, Jinjun |
| 作者单位 | 1.Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, ToxOm,NMS FCM, Lisbon, Portugal 2.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA 3.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Liyi,Zhang, Yang,Farokhzad, Ryan A.,et al. 'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective[J]. CHEMICAL SOCIETY REVIEWS,2023. |
| APA | Fu, Liyi,Zhang, Yang,Farokhzad, Ryan A.,Mendes, Barbara B.,Conde, Joao,&Shi, Jinjun.(2023).'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective.CHEMICAL SOCIETY REVIEWS. |
| MLA | Fu, Liyi,et al."'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective".CHEMICAL SOCIETY REVIEWS (2023). |
入库方式： OAI收割
来源：合肥物质科学研究院
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