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Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry

文献类型：期刊论文

作者Hu, Jun1,2; Liu, Youjiang1; Liu, Shaomin1; Li, Shan1; Wang, Han1,2; Chen, Chilai1
刊名CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
出版日期2023-10-01
卷号51
ISSN号0253-3820
关键词High-field asymmetric ion mobility spectrometry Scan speed Peak position Nonlinear function
DOI10.1016/j.cjac.2023.100305
通讯作者Chen, Chilai(chlchen@iim.ac.cn)
英文摘要High-field asymmetric waveform ion mobility spectrometry (FAIMS) enables precise identification of substances through fingerprint spectra obtained by multi-cycle scans at different separation voltages (DV) and nonlinear functions. To improve the scan speed of compensating voltage (CV) in multi-cycle scanning, the challenge arises in peak position shifts. This article proposes a method to accurately determine peak positions regardless of scan speed by exploiting the symmetric features of spectra obtained through positive and negative CV scans. The proposed method enables extremely fast scan speeds. A custom-built FAIMS system was used to verify the correlation between peak shifts and scan speed, the symmetry of spectra peaks under positive and negative CV scan modes, and the peak positions and solution errors of nonlinear functions by using benzene, styrene, acetone, toluene, m-xylene, and hydrogen sulfide as experimental samples. The results demonstrate the widespread occurrence of peak shifts, with peak deviations reaching as high as 2.49% even in slow scans of 0.75 V/s. As scan speed increases, peak position deviations gradually increase, with the maximum deviation reaching 46.83% at a scan speed of 30 V/s. By applying the proposed averaging method, peak positions of the six substances were obtained within the scan speed range of 30 to 0.75 V/s. Compared to traditional methods, the maximum peak position error using the averaging method was reduced by approximately 87.5%, and the spectrum acquisition time was reduced by 85%. The use of the averaging method reduced the calculation error of the alpha function by 88% and decreased the acquisition time by 80%. The research findings of this study offer a solution for the accurate determination of peak positions in FAIMS under fast scanning.
WOS关键词DISTORTION ; TIME
资助项目Strategic Priority Research Program of Chinese Academy of Sciences Deepsea and Hadal Intelligent Technology and Seafloor Science Laboratory[XDA22020503] ; National Natural Science Foundation of China[61871367]
WOS研究方向Chemistry
语种英语
出版者SCIENCE PRESS
WOS记录号WOS:001081424900001
资助机构Strategic Priority Research Program of Chinese Academy of Sciences Deepsea and Hadal Intelligent Technology and Seafloor Science Laboratory ; National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/133475]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Chilai
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Jun,Liu, Youjiang,Liu, Shaomin,et al. Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2023,51.
APA Hu, Jun,Liu, Youjiang,Liu, Shaomin,Li, Shan,Wang, Han,&Chen, Chilai.(2023).Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,51.
MLA Hu, Jun,et al."Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 51(2023).

入库方式： OAI收割

来源：合肥物质科学研究院

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