中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 中科院海岸带环境过程与生态修复重点实验室
Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota

文献类型：期刊论文

作者Xu, Ran3,4; Li, Li'ang3,4; Zheng, Jiahui3,4; Ji, Chenglong2; Wu, Huifeng2; Chen, Xiang3,4; Chen, Yuchuan3,4; Hu, Menghong3,4; Xu, Elvis Genbo1; Wang, Youji3,4
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2023-07-01
卷号880页码:9
ISSN号0048-9697
关键词Mytilus coruscus Antibiotic Biomarkers16S rRNA sequencing Joint toxicity
DOI10.1016/j.scitotenv.2023.163304
通讯作者Xu, Elvis Genbo(elvis@biology.sdu.dk) ; Wang, Youji(youjiwang2@gmail.com)
英文摘要Antibiotics and nanoplastics (NPs) are among the two most concerned and studied marine emerging contaminants in recent years. Given the large number of different types of antibiotics and NPs, there is a need to apply efficient tools to evaluate their combined toxic effects. Using the thick-shelled mussel (Mytilus coruscus) as a marine ecotoxicological model, we applied a battery of fast enzymatic activity assays and 16S rRNA sequencing to investigate the biochemical and gut microbial response of mussels exposed to antibiotic norfloxacin (NOR) and NPs (80 nm polystyrene beads) alone and in combination at environmentally relevant concentrations. After 15 days of exposure, NPs alone signifi-cantly inhibited superoxide dismutase (SOD) and amylase (AMS) activities, while catalase (CAT) was affected by both NOR and NPs. The changes in lysozyme (LZM) and lipase (LPS) were increased over time during the treatments. Co-exposure to NPs and NOR significantly affected glutathione (GSH) and trypsin (Typ), which might be explained by the increased bioavailable NOR carried by NPs. The richness and diversity of the gut microbiota of mussels were both decreased by exposures to NOR and NPs, and the top functions of gut microbiota that were affected by the exposures were predicted. The data fast generated by enzymatic test and 16S sequencing allowed further variance and correla-tion analysis to understand the plausible driving factors and toxicity mechanisms. Despite the toxic effects of only one type of antibiotics and NPs being evaluated, the validated assays on mussels are readily applicable to other anti-biotics, NPs, and their mixture.
WOS关键词OXIDATIVE STRESS ; ANTIBIOTICS ; WATER ; MICROPLASTICS ; SEA ; ENVIRONMENTS ; WASTEWATERS ; SEWAGE
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000981809500001
资助机构CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, YICCAS ; Innovation Program of Shanghai Municipal Education Commission ; Department of Biology, University of Southern Denmark ; Danmarks Frie Forskningsfond
源URL[http://ir.yic.ac.cn/handle/133337/32920]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Xu, Elvis Genbo; Wang, Youji
作者单位1.Univ Southern Denmark, Dept Biol, DK-5230 Odense M, Denmark
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
3.Shanghai Ocean Univ, Minist Educ, Key Lab Explorat & Utilizat Aquat Genet Resources, Shanghai 201306, Peoples R China
4.Shanghai Ocean Univ, Minist Sci & Technol, Coll Fisheries & Life Sci, Int Res Ctr Marine Biosci, Shanghai 201306, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Ran,Li, Li'ang,Zheng, Jiahui,et al. Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,880:9.
APA Xu, Ran.,Li, Li'ang.,Zheng, Jiahui.,Ji, Chenglong.,Wu, Huifeng.,...&Wang, Youji.(2023).Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota.SCIENCE OF THE TOTAL ENVIRONMENT,880,9.
MLA Xu, Ran,et al."Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota".SCIENCE OF THE TOTAL ENVIRONMENT 880(2023):9.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。