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Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment

文献类型：期刊论文

作者Li, Qing5; Yang, Yunhui4,5; Li, Yijian3; Mi, Yingqi1,5; Ma, Xuanxuan2; Jiang, Aili4; Guo, Zhanyong5
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2023-12-31
卷号253页码:13
ISSN号0141-8130
关键词Polysaccharide Chemical modification Coumarins
DOI10.1016/j.ijbiomac.2023.126691
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要Natural polysaccharides are abundant and renewable resource, but their applications are hampered by limited biological activity. Chemical modification can overcome these drawbacks by altering their structure. Three series of polysaccharide derivatives with coumarins were synthesized to obtain polysaccharide derivatives with enhanced biological activity. The biological activities were tested, including antioxidant property, antifungal property, and antibacterial property. Based on the results, the inhibitory properties of the coumarin-polysaccharide derivatives were significantly improved over the raw polysaccharide. The IC50 of the inhibition of DPPH, ABTS(center dot+), and superoxide (O-2(center dot-)) radical-scavenging was 0.06-0.15 mg/mL, 2.3-15.9 mu g/mL, and 0.03-0.25 mg/mL, respectively. Compared with the raw polysaccharides, coumarin-polysaccharide derivatives exhibited higher efficacy in inhibiting the growth of tested phytopathogens, showing inhibitory indices of 60.0-93.6 % at 1.0 mg/mL. Chitosan derivatives with methyl and chlorine (Compound 10B and 10C) exhibited significant antibacterial activity against S. aureus (MIC = 31.2 mu g/mL), E. coli (MIC = 7.8 mu g/mL), and V. harveyi (MIC = 15.6 mu g/mL), respectively. The results of the cytotoxicity assay showed no observed cytotoxicity when the RAW 264.7 cells were incubated with the synthesized polysaccharide derivatives at the tested concentrations.
WOS关键词RADICAL-SCAVENGING ACTIVITY ; ANTIOXIDANT ACTIVITY ; CHITOSAN DERIVATIVES ; ANTICANCER AGENTS ; DESIGN ; DPPH
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:001075112600001
资助机构Science and Technology Specific Projects in Agricul-tural High-tech Industrial Demonstration Area of the Yellow River Delta ; National Natural Science Foundation of China ; 2022 Central Guiding Local Science and Technology Development Fund Project in Shandong Province
源URL[http://ir.yic.ac.cn/handle/133337/32815]  
专题海岸带生物学与生物资源利用重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong
作者单位1.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China
2.Ludong Univ, Sch Resources & Environm Engn, Yantai 264025, Peoples R China
3.China Univ Petr, Coll Chemisry & Chem Engn, Qingdao 266580, Peoples R China
4.Yantai Univ, Coll Life Sci, Yantai 264003, Peoples R China
5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Li, Qing,Yang, Yunhui,Li, Yijian,et al. Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,253:13.
APA Li, Qing.,Yang, Yunhui.,Li, Yijian.,Mi, Yingqi.,Ma, Xuanxuan.,...&Guo, Zhanyong.(2023).Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,253,13.
MLA Li, Qing,et al."Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 253(2023):13.

入库方式： OAI收割

来源：烟台海岸带研究所

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