A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43
文献类型：期刊论文
| 作者 | Shi, Zhen-Zhen2; Yin, Xiu-Li2 ; Song, Yin-Ping2; Ji, Nai-Yun1,2
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2023-09-20 |
| 页码 | 5 |
| ISSN号 | 1612-1872 |
| 关键词 | antimicroalgal activity harziane diterpene steroid structure elucidation Trichoderma |
| DOI | 10.1002/cbdv.202301099 |
| 通讯作者 | Ji, Nai-Yun(nyji@yic.ac.cn) |
| 英文摘要 | One new diterpene, harziaketal A (1), and one new highly degraded sterol, trichosterol A (2), along with three known compounds, including one diterpene, harzianone (3), and two steroids, (22E,24R)-5 alpha,6 alpha-epoxy-ergosta-8(14),22-dien-3 ss,7 alpha-diol (4) and isoergokonin B (5), were isolated from the culture of the marine-alga-epiphytic fungus Trichoderma sp. Z43 by silica gel column chromatography (CC), Sephadex LH-20 CC, and preparative thin-layer chromatography (TLC). Their structures and relative configurations were assigned by nuclear magnetic resonance (NMR) and high resolution electrospray ionisation mass spectrometry (HR-ESI-MS) data, and the absolute configuration of 1 was established by X-ray diffraction. Compound 1 features a hemiketal unit situated at the four-membered ring of harziane-type diterpenes for the first time, while 2 represents the rare occurrence of sterols with rings A and B being degraded. Compounds 1 and 2 displayed weak inhibition against the tested phytoplankton (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense) with half maximal inhibitory concentration (IC50) ranging from 14 to 53 mu g/mL. |
| WOS关键词 | DEGRADED STEROLS ; INCISTEROLS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001068392300001 |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Taishan Scholar Project Special Funding ; Youth Innovation Promotion Association of the CAS |
| 源URL | [http://ir.yic.ac.cn/handle/133337/32869]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Ji, Nai-Yun |
| 作者单位 | 1.Shandong Saline Alkaline Land Modern Agr Co, Dongying 257345, Peoples R China 2.Chinese Acad Sci, Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Zhen-Zhen,Yin, Xiu-Li,Song, Yin-Ping,et al. A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43[J]. CHEMISTRY & BIODIVERSITY,2023:5. |
| APA | Shi, Zhen-Zhen,Yin, Xiu-Li,Song, Yin-Ping,&Ji, Nai-Yun.(2023).A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43.CHEMISTRY & BIODIVERSITY,5. |
| MLA | Shi, Zhen-Zhen,et al."A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43".CHEMISTRY & BIODIVERSITY (2023):5. |
入库方式： OAI收割
来源：烟台海岸带研究所
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