Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis
文献类型:期刊论文
作者 | Wang, Qi2,3; Li, Wenjun2,3; Hu, Haibo1; Lu, Xuechao1; Qin, Song2,3 |
刊名 | BIOMEDICINE & PHARMACOTHERAPY |
出版日期 | 2023-03-01 |
卷号 | 159页码:16 |
ISSN号 | 0753-3322 |
关键词 | Pulmonary fibrosis Monomeric compounds Flavonoids Alkaloid Terpenoids Phenols Saponins Quinones |
DOI | 10.1016/j.biopha.2023.114226 |
通讯作者 | Lu, Xuechao(hospitalbreathing@163.com) ; Qin, Song(sqin@yic.ac.cn) |
英文摘要 | Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, and can lead to decreased lung function, respiratory failure and even death. The pathogenesis research and treatment strategy of PF significantly lag behind the medical progress and clinical needs. The treatment of this disease remains a thorny clinical problem, and the effective therapeutic drugs are still limited. Monomeric compounds from traditional Chinese medicine own various biological activities and high safety. They play a broad part in treating diseases and is also a candidate drug for preventing and treating PF. In this paper, we reviewed the mechanism of action and potential value of various anti-PF monomeric compounds from traditional Chinese medicine. These monomeric com-pounds can attenuate inflammatory response, oxidative stress, epithelial mesenchymal transformation and other processes of lung through many signaling pathways, and inhibit the activation and differentiation of fibroblasts, thus contributing to the treatment of PF. This review can provide new ideas for the development of anti-PF drugs in high efficiency with low toxicity. |
WOS关键词 | NITRIC-OXIDE SYNTHASE ; INDUCED LUNG FIBROSIS ; INFLAMMATORY RESPONSE ; KAPPA-B ; INJURY ; ACTIVATION ; INHIBITION ; FIBROBLAST ; OXYMATRINE ; MICE |
WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000991197600001 |
资助机构 | National Key Research and Devel-opment Program ; Qingdao Scientific Research Project of TCM ; Shandong Science and Technology Development Project of TCM ; Qingdao Guidance Plan of Medical Science |
源URL | [http://ir.yic.ac.cn/handle/133337/32926] |
专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
通讯作者 | Lu, Xuechao; Qin, Song |
作者单位 | 1.Qingdao Hiser Hosp, Qingdao Hosp Tradit Chinese Med, Qingdao 266033, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Qi,Li, Wenjun,Hu, Haibo,et al. Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,159:16. |
APA | Wang, Qi,Li, Wenjun,Hu, Haibo,Lu, Xuechao,&Qin, Song.(2023).Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis.BIOMEDICINE & PHARMACOTHERAPY,159,16. |
MLA | Wang, Qi,et al."Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis".BIOMEDICINE & PHARMACOTHERAPY 159(2023):16. |
入库方式: OAI收割
来源:烟台海岸带研究所
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