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Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives

文献类型：期刊论文

作者Cheng, Zhongquan8,9; Shang, Jihuan10; Wang, Huarong8; Yu, Leyi11; Yuan, Zhu1,8; Zhang, Yinlong5,12; Du, Yang4,6,9; Tian, Jie2,3,7,9
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2023-10-01
卷号362页码:97-120
关键词Extracellular vesicles Molecular imaging Cancer Diagnosis Therapy
ISSN号0168-3659
DOI10.1016/j.jconrel.2023.08.040
通讯作者Yuan, Zhu(BJFH_yz_paper@163.com) ; Zhang, Yinlong(zhangyl@nanoctr.cn) ; Du, Yang(yang.du@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
英文摘要Extracellular vesicles (EVs), the mediators of intercellular communication, have attracted the attention of researchers for the important roles they play in cancer treatment. Compared with other inorganic nano-materials, EVs possess the advantages of higher biocompatibility, better physiochemical stability, easier surface modification, and excellent biosafety. They can be used as an advanced drug delivery system with an improved therapeutic index for various therapeutic agents. Engineered EV-based imaging and therapeutic agents (engineered EVs) have emerged as useful tools in targeted cancer diagnosis and therapy. Non-invasive tracing of engineered EVs contributes to a better evaluation of their functions in cancer progression, in vivo dynamic biodistribution, therapeutic response, and drug-loading efficiency. Recent advances in real-time molecular imaging (MI), and innovative EV labeling strategies have led to the development of novel tools that can evaluate the pharmacokinetics of engineered EVs in cancer management, which may accelerate further clinical translation of novel EV-based drug delivery platforms. Herein, we review the latest advances in EVs, their characteristics, and current examples of EV-based targeted drug delivery for cancer. Then, we discuss the prominent applications of MI for tracing both natural and engineered EVs. Finally, we discuss the current challenges and considerations of EVs in targeted cancer treatment and the limitations of different MI modalities. In the coming decades, EV-based
WOS关键词EXOSOME-MEDIATED DELIVERY ; STEM-CELLS ; ENGINEERED EXOSOMES ; COLON-CANCER ; BIODISTRIBUTION ; NANOPARTICLES ; STRATEGIES ; THERAPY ; SYSTEM ; MICROVESICLES
资助项目National Natural Science Foundation of China[82272111] ; National Natural Science Foundation of China[62027901,92159303] ; National Natural Science Foundation of China[81871514] ; Beijing Natural Science Foundation[7212207]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001075462300001
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/53143]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Yuan, Zhu; Zhang, Yinlong; Du, Yang; Tian, Jie
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Beijing 100190, Peoples R China
2.Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Med, Beijing, Peoples R China
3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med Sci & Engn, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Sch Nanosci & Engn, Beijing 100049, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
7.Beihang Univ, Sci & Engn, Beijing 100191, Peoples R China
8.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
9.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
10.Nanjing Med Univ, Sch Clin Med, Nanjing 211166, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Zhongquan,Shang, Jihuan,Wang, Huarong,et al. Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives[J]. JOURNAL OF CONTROLLED RELEASE,2023,362:97-120.
APA Cheng, Zhongquan.,Shang, Jihuan.,Wang, Huarong.,Yu, Leyi.,Yuan, Zhu.,...&Tian, Jie.(2023).Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives.JOURNAL OF CONTROLLED RELEASE,362,97-120.
MLA Cheng, Zhongquan,et al."Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives".JOURNAL OF CONTROLLED RELEASE 362(2023):97-120.

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来源：自动化研究所

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