中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early-Stage Glioblastoma Based on a Biomimetic Nanoplatform

文献类型：期刊论文

作者Huang, Xiazi1,2,4; Hui, Hui2; Shang, Wenting2; Gao, Pengli2; Zhou, Yingying1,4; Pang, Weiran1,4; Woo, Chi Man1,4; Lai, Puxiang1,3,4; Tian, Jie2
刊名ADVANCED SCIENCE
出版日期2023-05-07
页码11
关键词biomimetic nanoplatform brain-blood-barrier breaking cancer diagnosis glioblastoma multiforme magnetic particle imaging
DOI10.1002/advs.202300854
通讯作者Lai, Puxiang(puxiang.lai@polyu.edu.hk) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Early diagnosis can effectively improve the survival of glioblastoma multiforme (GBM). A specific imaging technique that is simultaneously deep penetrating and sensitive to small tissue changes is desired to identify GBM. Due to its excellent features in signal contrast, detection sensitivity, and none or little attenuation in tissue, magnetic particle imaging (MPI) possesses great potential in cancer diagnosis, especially when the imaging modality is equipped with specifically targeted nanoprobes. However, when gliomas are small, the blood-brain barrier (BBB) is complete and prevents nanoprobes from entering the brain, which negates the theranostic effect. This study proposes a biomimetic nanoplatform that assist the MPI tracers in breaking through the BBB and then demonstrate a targeted and sensitive diagnosis of GBM. Afterward, the photothermal therapy and immune regulation show an excellent therapeutic effect on the GBM. It is experimentally confirmed that the MPI signal does not decay with tissue depth and shows excellent sensitivity for thousands-cells. Only small animals are conducted in this study due to the limitations of the current commercial MPI scanner, however, this research theoretically enables large animal and human studies, which encourages a promising pathway toward the noninvasive diagnosis of early-stage GBM in clinics.
WOS关键词DRUG-DELIVERY ; TUMORS
资助项目National Natural Science Foundation of China[81930048] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81227901] ; Beijing Natural Science Foundation[JQ22023] ; Guangdong Science and Technology Commission[2019BT02x105] ; Hong Kong Innovation and Technology Commission[GHP/043/19SZ] ; Hong Kong Innovation and Technology Commission[GHP/044/19GD] ; Hong Kong Research Grant Council[15217721] ; Hong Kong Research Grant Council[R5029-19] ; Hong Kong Research Grant Council[C7074-21GF] ; Hong Kong Polytechnic University[P0038180] ; Hong Kong Polytechnic University[P0039517] ; Hong Kong Polytechnic University[P0043485] ; Guangdong Key Research and Development Program of China[2021B0101420005] ; Project of High-Level Talents Team Introduction in Zhuhai City (Zhuhai)[HLHPTP201703] ; Multimodal Biomedical Imaging Experimental Platform, Institute of Automation, Chinese Academy of Sciences
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:000982684900001
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Guangdong Science and Technology Commission ; Hong Kong Innovation and Technology Commission ; Hong Kong Research Grant Council ; Hong Kong Polytechnic University ; Guangdong Key Research and Development Program of China ; Project of High-Level Talents Team Introduction in Zhuhai City (Zhuhai) ; Multimodal Biomedical Imaging Experimental Platform, Institute of Automation, Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/53314]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Lai, Puxiang; Tian, Jie
作者单位1.Hong Kong Polytech Univ, Dept Biomed Engn, Hong Kong 000000, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Hong Kong Polytech Univ, Photon Res Inst, Hong Kong 000000, Peoples R China
4.Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Xiazi,Hui, Hui,Shang, Wenting,et al. Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early-Stage Glioblastoma Based on a Biomimetic Nanoplatform[J]. ADVANCED SCIENCE,2023:11.
APA Huang, Xiazi.,Hui, Hui.,Shang, Wenting.,Gao, Pengli.,Zhou, Yingying.,...&Tian, Jie.(2023).Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early-Stage Glioblastoma Based on a Biomimetic Nanoplatform.ADVANCED SCIENCE,11.
MLA Huang, Xiazi,et al."Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early-Stage Glioblastoma Based on a Biomimetic Nanoplatform".ADVANCED SCIENCE (2023):11.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。