Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice
文献类型：期刊论文
| 作者 | Lu, Jing22,23; Liang, Feng12,21,22; Bai, Ping1,20,21; Liu, Chenghao19,21,22; Xu, Miao18,21,22; Sun, Zhengwang21,22; Tian, Wenjie15,16,17,21; Dong, Yuanlin21,22; Zhang, Yiying21,22; Quan, Qimin14 |
| 刊名 | ALZHEIMERS & DEMENTIA
 |
| 出版日期 | 2023-05-30 |
| 页码 | 17 |
| ISSN号 | 1552-5260 |
| 关键词 | anesthesia delirium phosphorylated tau at threonine 217 surgery tau tau phosphorylation |
| DOI | 10.1002/alz.13118 |
| 通讯作者 | Yang, Guang(gy2268@cumc.columbia.edu) ; Xie, Zhongcong(zxie@mgh.harvard.edu) |
| 英文摘要 | INTRODUCTIONBlood phosphorylated tau at threonine 217 (tau-PT217) is a newly established biomarker for Alzheimer's disease and postoperative delirium in patients. However, the mechanisms and consequences of acute changes in blood tau-PT217 remain largely unknown. METHODSWe investigated the effects of anesthesia/surgery on blood tau-PT217 in aged mice, and evaluated the associated changes in B cell populations, neuronal excitability in anterior cingulate cortex, and delirium-like behavior using positron emission tomography imaging, nanoneedle technology, flow cytometry, electrophysiology, and behavioral tests. RESULTSAnesthesia/surgery induced acute increases in blood tau-PT217 via enhanced generation in the lungs and release from B cells. Tau-PT217 might cross the blood-brain barrier, increasing neuronal excitability and inducing delirium-like behavior. B cell transfer and WS635, a mitochondrial function enhancer, mitigated the anesthesia/surgery-induced changes. DISCUSSIONAcute increases in blood tau-PT217 may contribute to brain dysfunction and postoperative delirium. Targeting B cells or mitochondrial function may have therapeutic potential for preventing or treating these conditions. |
| WOS关键词 | ALZHEIMERS-DISEASE ; PERMEABILITY TRANSITION ; POSTOPERATIVE DELIRIUM ; COGNITIVE DYSFUNCTION ; RISK-FACTORS ; TAU ; REDUCTION ; DEMENTIA ; DEFICITS ; CYCLOSPORINE |
| 资助项目 | National Institutes of Health[AG062509] ; National Institutes of Health[AG070761] ; National Institutes of Health[AG051812] ; [AG041274] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000997439800001 |
| 资助机构 | National Institutes of Health |
| 源URL | [http://ir.ia.ac.cn/handle/173211/53326]  |
| 专题 | 数字内容技术与服务研究中心_听觉模型与认知计算 |
| 通讯作者 | Yang, Guang; Xie, Zhongcong |
| 作者单位 | 1.Sichuan Univ, West China Hosp, Precis Med Key Lab Sichuan Prov, Targeted Tracer Res & Dev Lab, Chengdu, Peoples R China 2.Columbia Univ, Irving Med Ctr, Dept Anesthesiol, Anesthesia, New York, NY 10032 USA 3.Harvard Med Sch, 149 13th St,Room 4310, Charlestown, MA 02129 USA 4.Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Anesthesia, 149 13th St,Room 4310, Charlestown, MA 02129 USA 5.Columbia Univ, Med Ctr, Dept Anesthesiol, New York, NY USA 6.Univ Penn Hlth Syst, Perelman Sch Med, Dept Anesthesiol & Crit Care, Philadelphia, PA USA 7.Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA USA 8.Beth Israel Deaconess Med Ctr, Dept Med, Div Gerontol, Boston, MA USA 9.Beth Israel Deaconess Med Ctr, Dept Med, Div Gen Med & Primary Care, Boston, MA USA 10.Shanghai Jiao Tong Univ, Sch Med, Mental Hlth Ctr, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Jing,Liang, Feng,Bai, Ping,et al. Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice[J]. ALZHEIMERS & DEMENTIA,2023:17. |
| APA | Lu, Jing.,Liang, Feng.,Bai, Ping.,Liu, Chenghao.,Xu, Miao.,...&Xie, Zhongcong.(2023).Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice.ALZHEIMERS & DEMENTIA,17. |
| MLA | Lu, Jing,et al."Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice".ALZHEIMERS & DEMENTIA (2023):17. |
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来源：自动化研究所
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