Effects of Microstate Dynamic Brain Network Disruption in Different Stages of Schizophrenia
文献类型：期刊论文
| 作者 | Yan, Tianyi2; Wang, Gongshu2; Liu, Tiantian2; Li, Guoqi1 ; Wang, Changming4; Funahashi, Shintaro3; Suo, Dingjie2; Pei, Guangying2
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| 刊名 | IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
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| 出版日期 | 2023 |
| 卷号 | 31页码:2688-2697 |
| ISSN号 | 1534-4320 |
| 关键词 | Dynamic brain network information interaction microstates resting-state EEG schizophrenia stages |
| DOI | 10.1109/TNSRE.2023.3283708 |
| 通讯作者 | Suo, Dingjie(suo@bit.edu.cn) ; Pei, Guangying(pei_guangying@bit.edu.cn) |
| 英文摘要 | Schizophrenia is a heterogeneous mental disorder with unknown etiology or pathological characteristics. Microstate analysis of the electroencephalogram (EEG) signal has shown significant potential value for clinical research. Importantly, significant changes in microstate-specific parameters have been extensively reported; however, these studies have ignored the information interactions within the microstate network in different stages of schizophrenia. Based on recent findings, since rich information about the functional organization of the brain can be revealed by functional connectivity dynamics, we use the first-order autoregressive model to construct the functional connectivity of intra- and intermicrostate networks to identify information interactions among microstate networks. We demonstrate that, beyond abnormal parameters, disrupted organization of the microstate networks plays a crucial role in different stages of the disease by 128-channel EEG data collected from individuals with first-episode schizophrenia, ultrahigh-risk, familial high-risk, and healthy controls. According to the characteristics of the microstates of patients at different stages, the parameters of microstate class A are reduced, those of class C are increased, and the transitions from intra- to intermicrostate functional connectivity are gradually disrupted. Furthermore, decreased integration of intermicrostate information might lead to cognitive deficits in individuals with schizophrenia and those in high-risk states. Taken together, these findings illustrate that the dynamic functional connectivity of intra- and intermicrostate networks captures more components of disease pathophysiology. Our work sheds new light on the characterization of dynamic functional brain networks based on EEG signals and provides a new interpretation of aberrant brain function in different stages of schizophrenia from the perspective of microstates. |
| WOS关键词 | FUNCTIONAL CONNECTIVITY ; EEG ; INSIGHTS ; COMMON ; PHASE ; NAIVE |
| 资助项目 | Scientific and Technological Innovation (STI) 2030-Major Projects[2022ZD0208500] ; National Natural Science Foundation of China[U20A20191] ; National Natural Science Foundation of China[82071912] ; National Natural Science Foundation of China[12104049] ; National Natural Science Foundation of China[82202291] ; Fundamental Research Funds for the Central Universities[2023CX01024] |
| WOS研究方向 | Engineering ; Rehabilitation |
| 语种 | 英语 |
| 出版者 | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC |
| WOS记录号 | WOS:001012664600002 |
| 资助机构 | Scientific and Technological Innovation (STI) 2030-Major Projects ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ia.ac.cn/handle/173211/53573]  |
| 专题 | 数字内容技术与服务研究中心_听觉模型与认知计算 |
| 通讯作者 | Suo, Dingjie; Pei, Guangying |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 2.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 3.Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China 4.Capital Med Univ, XuanWu Hosp, Dept Neurosurg, Beijing 100088, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Tianyi,Wang, Gongshu,Liu, Tiantian,et al. Effects of Microstate Dynamic Brain Network Disruption in Different Stages of Schizophrenia[J]. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING,2023,31:2688-2697. |
| APA | Yan, Tianyi.,Wang, Gongshu.,Liu, Tiantian.,Li, Guoqi.,Wang, Changming.,...&Pei, Guangying.(2023).Effects of Microstate Dynamic Brain Network Disruption in Different Stages of Schizophrenia.IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING,31,2688-2697. |
| MLA | Yan, Tianyi,et al."Effects of Microstate Dynamic Brain Network Disruption in Different Stages of Schizophrenia".IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 31(2023):2688-2697. |
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