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Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder

文献类型：期刊论文

作者Li, Xuemei9; Huang, Yang10; Liu, Mengqi10; Zhang, Manqi7,11; Liu, Yang10; Teng, Teng9; Liu, Xueer9; Yu, Ying4; Jiang, Yuanliang9; Ouyang, Xuan7,11
刊名INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
出版日期2023-10-01
卷号23期号:4页码:9
关键词Childhood trauma Major depressive disorder Adolescent Functional neuroimaging Brain network
ISSN号1697-2600
DOI10.1016/j.ijchp.2023.100401
通讯作者Long, Yicheng(yichenglong@csu.edu.cn) ; Zhou, Xinyu(zhouxinyu@cqmu.edu.cn)
英文摘要Childhood trauma is a leading risk factor for adolescents developing major depressive disorder (MDD); however, the underlying neuroimaging mechanisms remain unclear. This study aimed to investigate the association among childhood trauma, MDD and brain dysfunctions by combining static and dynamic brain network models. We recruited 46 first-episode drug-naive adolescent MDD patients with childhood trauma (MDD-CT), 53 MDD patients without childhood trauma (MDD-nCT), and 90 healthy controls (HCs) for resting-state functional magnetic resonance imaging (fMRI) scans; all participants were aged 13-18 years. Compared to the HCs and MDD-nCT groups, the MDD-CT group exhibited significantly higher global and local efficiency in static brain networks and significantly higher temporal correlation coefficients in dynamic brain network models at the whole-brain level, and altered the local efficiency of default mode network (DMN) and temporal correlation coefficients of DMN, salience (SAN), and attention (ATN) networks at the local perspective. Correlation analysis indicated that altered brain network features and clinical symptoms, childhood trauma, and particularly emotional neglect were highly correlated in adolescents with MDD. This study may provide new evidence for the dysconnectivity hypothesis regarding the associations between childhood trauma and MDD in adolescents from the perspectives of both static and dynamic brain topology.
WOS关键词TEST-RETEST RELIABILITY ; DEFAULT-MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; FMRI ; ORGANIZATION ; ARCHITECTURE ; METAANALYSIS ; ADVERSITIES ; ASSOCIATION ; RUMINATION
资助项目STI2030-Major Projects[82271565] ; National Natural Science Foundation of China[82201692] ; National Natural Science Foundation of China[cstc2020jcyj-jqX0024] ; Chongqing Outstanding Youth Foundation ; [2022ZD0212900]
WOS研究方向Psychology
语种英语
WOS记录号WOS:001053489700001
出版者ELSEVIER SCIENCE INC
资助机构STI2030-Major Projects ; National Natural Science Foundation of China ; Chongqing Outstanding Youth Foundation
源URL[http://ir.ia.ac.cn/handle/173211/53945]  
专题自动化研究所_脑网络组研究中心
通讯作者Long, Yicheng; Zhou, Xinyu
作者单位1.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing, Peoples R China
2.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, 139 Renmin Middle Rd, Changsha, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
6.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Renmin Middle Rd, Changsha, Peoples R China
7.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China
8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China
10.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xuemei,Huang, Yang,Liu, Mengqi,et al. Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2023,23(4):9.
APA Li, Xuemei.,Huang, Yang.,Liu, Mengqi.,Zhang, Manqi.,Liu, Yang.,...&Zhou, Xinyu.(2023).Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,23(4),9.
MLA Li, Xuemei,et al."Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 23.4(2023):9.

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来源：自动化研究所

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