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Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders

文献类型：期刊论文

作者Long, Yicheng11,12; Li, Xuemei9; Cao, Hengyi4,10; Zhang, Manqi2; Lu, Bing3,6; Huang, Yang1; Liu, Mengqi1; Xu, Ming5,6,7; Liu, Zhening11,12; Yan, Chaogan3,6
刊名PSYCHOLOGICAL MEDICINE
出版日期2023-08-09
页码10
ISSN号0033-2917
关键词Aging brain network connectome functional connectivity major depressive disorder
DOI10.1017/S0033291723002234
通讯作者Sui, Jing(jsui@bnu.edu.cn) ; Ouyang, Xuan(ouyangxuan@csu.edu.cn) ; Zhou, Xinyu(zhouxinyu@cqmu.edu.cn)
英文摘要BackgroundThe age-related heterogeneity in major depressive disorder (MDD) has received significant attention. However, the neural mechanisms underlying such heterogeneity still need further investigation. This study aimed to explore the common and distinct functional brain abnormalities across different age groups of MDD patients from a large-sample, multicenter analysis. MethodsThe analyzed sample consisted of a total of 1238 individuals including 617 MDD patients (108 adolescents, 12-17 years old; 411 early-middle adults, 18-54 years old; and 98 late adults, > = 55 years old) and 621 demographically matched healthy controls (60 adolescents, 449 early-middle adults, and 112 late adults). MDD-related abnormalities in brain functional connectivity (FC) patterns were investigated in each age group separately and using the whole pooled sample, respectively. ResultsWe found shared FC reductions among the sensorimotor, visual, and auditory networks across all three age groups of MDD patients. Furthermore, adolescent patients uniquely exhibited increased sensorimotor-subcortical FC; early-middle adult patients uniquely exhibited decreased visual-subcortical FC; and late adult patients uniquely exhibited wide FC reductions within the subcortical, default-mode, cingulo-opercular, and attention networks. Analysis of covariance models using the whole pooled sample further revealed: (1) significant main effects of age group on FCs within most brain networks, suggesting that they are decreased with aging; and (2) a significant age group x MDD diagnosis interaction on FC within the default-mode network, which may be reflective of an accelerated aging-related decline in default-mode FCs. ConclusionsTo summarize, these findings may deepen our understanding of the age-related biological and clinical heterogeneity in MDD.
WOS关键词DEFAULT-MODE NETWORK ; LATE-LIFE DEPRESSION ; OLDER-ADULTS ; CONNECTIVITY ; 1ST-EPISODE ; YOUNGER ; ONSET ; AGE
资助项目STI2030-Major Projects[2022ZD0212900] ; National Natural Science Foundation of China[82271565] ; National Natural Science Foundation of China[82201692] ; National Natural Science Foundation of China[82071506] ; Natural Science Foundation of Hunan Province, China[2021JJ40851]
WOS研究方向Psychology ; Psychiatry
语种英语
出版者CAMBRIDGE UNIV PRESS
WOS记录号WOS:001044055700001
资助机构STI2030-Major Projects ; National Natural Science Foundation of China ; Natural Science Foundation of Hunan Province, China
源URL[http://ir.ia.ac.cn/handle/173211/53990]  
专题自动化研究所_脑网络组研究中心
通讯作者Sui, Jing; Ouyang, Xuan; Zhou, Xinyu
作者单位1.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China
2.South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Peoples R China
3.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
8.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China
10.Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA
推荐引用方式
GB/T 7714		 Long, Yicheng,Li, Xuemei,Cao, Hengyi,et al. Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders[J]. PSYCHOLOGICAL MEDICINE,2023:10.
APA Long, Yicheng.,Li, Xuemei.,Cao, Hengyi.,Zhang, Manqi.,Lu, Bing.,...&Zhou, Xinyu.(2023).Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders.PSYCHOLOGICAL MEDICINE,10.
MLA Long, Yicheng,et al."Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders".PSYCHOLOGICAL MEDICINE (2023):10.

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来源：自动化研究所

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