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State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex

文献类型：期刊论文

作者Cao, Dan2; Liu, Qihong5; Zhang, Jiaqi2,4; Li, Jin1; Jiang, Tianzi2,3,4
刊名BRAIN STIMULATION
出版日期2023-07-01
卷号16期号:4页码:1112-1122
关键词Intracranial electrical stimulation Orbitofrontal cortex State-specific modulation Emotional network Intracranial EEG
ISSN号1935-861X
DOI10.1016/j.brs.2023.07.049
通讯作者Li, Jin(jli@nlpr.ia.ac.cn) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要Background: Orbitofrontal cortex (OFC) is a promising target for intracranial electrical stimulation (iES) aimed at improving mood states. However, knowledge gaps remain regarding the underlying neural mechanisms of iES effects, such as the effect of the OFC target in comparison with other emotional network targets, the impact of brain state at the time of stimulation, and the neural response induced by iES at both local and network scales. Objective: Our study aims to address the neural mechanisms underlying the effects of iES in improving mood states. Methods: We conducted a study in 24 epilepsy patients who received iES through implanted electrodes in the emotional network and compared the effects of iES on multiple targets in the emotional network. Results: We found that only iES applied to the orbitofrontal cortex (OFC) led to mood improvement and changes in neural activity. We also observed that iES to the OFC suppressed the delta-theta power when the brain was in a low mood state. Moreover, the iES to the OFC decreased delta-theta power and increased gamma power at local regions within the emotional network, and enhanced the information flow through the frequency domain among regions within the emotional network. Conclusions: These findings provide insight into the neural correlates of iES-induced mood improvement and support the potential of iES as a therapeutic intervention for mood disorders.
WOS关键词PROBABILISTIC FUNCTIONAL TRACTOGRAPHY ; CIRCUITS ; EMOTION ; REWARD
资助项目STI2030-Major Projects[32271085] ; National Natural Science Foundation of China[82151307] ; National Natural Science Foundation of China[CNLYB2004] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[2022KI0AC02] ; Key Research Project of Zhejiang Lab[2022ND0AN01] ; [2021ZD0200200]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001057252300001
出版者ELSEVIER SCIENCE INC
资助机构STI2030-Major Projects ; National Natural Science Foundation of China ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; Key Research Project of Zhejiang Lab
源URL[http://ir.ia.ac.cn/handle/173211/54068]  
专题自动化研究所_脑网络组研究中心
通讯作者Li, Jin; Jiang, Tianzi
作者单位1.Capital Normal Univ, Sch Psychol, Beijing 100048, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
3.Zhejiang Lab, Res Ctr Augmented Intelligence, Hangzhou 311100, Peoples R China
4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Dan,Liu, Qihong,Zhang, Jiaqi,et al. State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex[J]. BRAIN STIMULATION,2023,16(4):1112-1122.
APA Cao, Dan,Liu, Qihong,Zhang, Jiaqi,Li, Jin,&Jiang, Tianzi.(2023).State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex.BRAIN STIMULATION,16(4),1112-1122.
MLA Cao, Dan,et al."State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex".BRAIN STIMULATION 16.4(2023):1112-1122.

入库方式： OAI收割

来源：自动化研究所

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