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Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging

文献类型：期刊论文

作者Li, Wenjing5,6; Pang, Yiyun1; Jin, Kehan1; Wang, Yuru1; Wu, Yujie6; Luo, Jichang3,4; Xu, Wenlong3,4; Zhang, Xiao3,4; Xu, Ran3,4; Wang, Tao3,4
刊名WIRES MECHANISMS OF DISEASE
出版日期2023-05-08
页码24
ISSN号2692-9368
关键词cardiovascular diseases cellular organelles cholesterol membrane contact sites vascular aging
DOI10.1002/wsbm.1612
通讯作者Xu, Ran(xrqssq@126.com) ; Wang, Tao(wangtao_dr@sina.com) ; Jiao, Liqun(liqunjiao@sina.cn)
英文摘要Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification, the processes executed by multiple organelles. Moreover, organelles responsible for cholesterol homeostasis are spatially and functionally coordinated instead of isolated by forming the membrane contact sites. Membrane contact, mediated by specific protein-protein interaction, pulls opposing organelles together and creates the hybrid place for cholesterol transfer and further signaling. The membrane contact-dependent cholesterol transfer, together with the vesicular transport, maintains cholesterol homeostasis and has intimate implications in a growing list of diseases, including vascular aging-related diseases. Here, we summarized the latest advances regarding cholesterol homeostasis by highlighting the membrane contact-based regulatory mechanism. We also describe the downstream signaling under cholesterol homeostasis perturbations, prominently in cholesterol-rich conditions, stimulating age-dependent organelle dysfunction and vascular aging. Finally, we discuss potential cholesterol-targeting strategies for therapists regarding vascular aging-related diseases.This article is categorized under:Cardiovascular Diseases > Molecular and Cellular Physiology
WOS关键词FOAM CELL-FORMATION ; COOPERATIVE BINDING ; NLRP3 INFLAMMASOME ; RECEPTOR ; TRANSPORT ; MITOCHONDRIA ; ACTIVATION ; MECHANISMS ; ER ; ATHEROSCLEROSIS
资助项目Beijing Municipal Science & Technology Commission[5202022] ; National Natural Science Foundation of China[82171303] ; National Natural Science Foundation of China[91954201]
WOS研究方向Research & Experimental Medicine
语种英语
出版者WILEY
WOS记录号WOS:000985049100001
资助机构Beijing Municipal Science & Technology Commission ; National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/53209]  
专题多模态人工智能系统全国重点实验室
通讯作者Xu, Ran; Wang, Tao; Jiao, Liqun
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Intervent Radiol, Beijing, Peoples R China
3.China Int Neurosci Inst China INI, Beijing, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Lab Computat Biol & Machine Intelligence, Natl Lab Pattern Recognit, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Wenjing,Pang, Yiyun,Jin, Kehan,et al. Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging[J]. WIRES MECHANISMS OF DISEASE,2023:24.
APA Li, Wenjing.,Pang, Yiyun.,Jin, Kehan.,Wang, Yuru.,Wu, Yujie.,...&Jiao, Liqun.(2023).Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging.WIRES MECHANISMS OF DISEASE,24.
MLA Li, Wenjing,et al."Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging".WIRES MECHANISMS OF DISEASE (2023):24.

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来源：自动化研究所

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