Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex
文献类型：期刊论文
| 作者 | Shao, Tiannan2,5; Huang, Jing2,5; Zhao, Yuxin1,11,12; Wang, Weiyan2,5; Tian, Xiaohan10; Hei, Gangrui9; Kang, Dongyu2,5; Gao, Yong8; Liu, Fangkun7; Zhao, Jingping2,5 |
| 刊名 | TRANSLATIONAL PSYCHIATRY
 |
| 出版日期 | 2023-10-11 |
| 卷号 | 13期号:1页码:10 |
| ISSN号 | 2158-3188 |
| DOI | 10.1038/s41398-023-02616-x |
| 通讯作者 | Wu, Renrong(wurenrong@csu.edu.cn) |
| 英文摘要 | Cognitive impairment is a core feature of schizophrenia, which is aggravated by antipsychotics-induced metabolic disturbance and lacks effective pharmacologic treatments in clinical practice. Our previous study demonstrated the efficiency of metformin in alleviating metabolic disturbance following antipsychotic administration. Here we report that metformin could ameliorate cognitive impairment and improve functional connectivity (FC) in prefrontal regions. This is an open-labeled, evaluator-blinded study. Clinically stable patients with schizophrenia were randomly assigned to receive antipsychotics plus metformin (N = 48) or antipsychotics alone (N = 24) for 24 weeks. The improvement in cognition was assessed by the MATRICS Consensus Cognitive Battery (MCCB). Its association with metabolic measurements, and voxel-wise whole-brain FC with dorsolateral prefrontal cortex (DLPFC) subregions as seeds were evaluated. When compared to the antipsychotics alone group, the addition of metformin resulted in significantly greater improvements in the MCCB composite score, speed of processing, working memory, verbal learning, and visual learning. A significant time x group interaction effect of increased FC between DLPFC and the anterior cingulate cortex (ACC)/middle cingulate cortex (MCC), and between DLPFC subregions were observed after metformin treatment, which was positively correlated with MCCB cognitive performance. Furthermore, the FC between left DLPFC A9/46d to right ACC/MCC significantly mediated metformin-induced speed of processing improvement; the FC between left A46 to right ACC significantly mediated metformin-induced verbal learning improvement. Collectively, these findings demonstrate that metformin can improve cognitive impairments in schizophrenia patients and is partly related to the FC changes in the DLPFC. Trial Registration: The trial was registered with ClinicalTrials.gov (NCT03271866). The full trial protocol is provided in Supplementary Material. |
| WOS关键词 | DOUBLE-BLIND ; DRUG-NAIVE ; BRAIN ; 1ST-EPISODE ; DYSFUNCTION ; WEIGHT ; RISK ; LIFE |
| 资助项目 | This work was supported by the National Natural Science Foundation of China (Grant Nos. 81622018 and 82072096).[81622018] ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 81622018 and 82072096).[82072096] ; National Natural Science Foundation of China |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | SPRINGERNATURE |
| WOS记录号 | WOS:001079330300001 |
| 资助机构 | This work was supported by the National Natural Science Foundation of China (Grant Nos. 81622018 and 82072096). ; National Natural Science Foundation of China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/53041]  |
| 专题 | 脑图谱与类脑智能实验室 |
| 通讯作者 | Wu, Renrong |
| 作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China 3.Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China 4.Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Shanghai Key Lab Anesthesiol & Brain Funct Modulat, Shanghai 200434, Peoples R China 5.Central South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Peoples R China 6.Shanghai Jiao Tong Univ, Brain Hlth Inst, Natl Ctr Mental Disorders, Sch Med,Shanghai Mental Hlth Ctr,Shanghai Key Lab, Shanghai 200030, Peoples R China 7.Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Peoples R China 8.Cent South Univ, Changde Hosp, Peoples Hosp Changde 1, Xiangya Med Coll ,Dept Orthoped, Changde 415900, Peoples R China 9.Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou 450052, Peoples R China 10.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Tiannan,Huang, Jing,Zhao, Yuxin,et al. Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex[J]. TRANSLATIONAL PSYCHIATRY,2023,13(1):10. |
| APA | Shao, Tiannan.,Huang, Jing.,Zhao, Yuxin.,Wang, Weiyan.,Tian, Xiaohan.,...&Wu, Renrong.(2023).Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex.TRANSLATIONAL PSYCHIATRY,13(1),10. |
| MLA | Shao, Tiannan,et al."Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex".TRANSLATIONAL PSYCHIATRY 13.1(2023):10. |
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