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Shank3 mutations enhance early neural responses to deviant tones in dogs

文献类型：期刊论文

作者Wu, Liang4,5; Mei, Shuting1; Yu, Shan2,3; Han, Shihui1; Zhang, Yong Q.4,5
刊名CEREBRAL CORTEX
出版日期2023-08-16
页码12
ISSN号1047-3211
关键词auditory processing autism dog electrocorticogram Shank3
DOI10.1093/cercor/bhad302
通讯作者Han, Shihui(shan@pku.edu.cn) ; Zhang, Yong Q.(yqzhang@genetics.ac.cn)
英文摘要Both enhanced discrimination of low-level features of auditory stimuli and mutations of SHANK3 (a gene that encodes a synaptic scaffolding protein) have been identified in autism spectrum disorder patients. However, experimental evidence regarding whether SHANK3 mutations lead to enhanced neural processing of low-level features of auditory stimuli is lacking. The present study investigated this possibility by examining effects of Shank3 mutations on early neural processing of pitch (tone frequency) in dogs. We recorded electrocorticograms from wild-type and Shank3 mutant dogs using an oddball paradigm in which deviant tones of different frequencies or probabilities were presented along with other tones in a repetitive stream (standards). We found that, relative to wild-type dogs, Shank3 mutant dogs exhibited larger amplitudes of early neural responses to deviant tones and greater sensitivity to variations of deviant frequencies within 100 ms after tone onsets. In addition, the enhanced early neural responses to deviant tones in Shank3 mutant dogs were observed independently of the probability of deviant tones. Our findings highlight an essential functional role of Shank3 in modulations of early neural detection of novel sounds and offer new insights into the genetic basis of the atypical auditory information processing in autism patients.
WOS关键词AUTISM SPECTRUM DISORDER ; MISMATCH NEGATIVITY ; DISCRIMINATION ; PROTEINS ; LATENCY ; BRAIN ; PROBABILITY ; INTEGRATION ; POTENTIALS ; MECHANISMS
WOS研究方向Neurosciences & Neurology
语种英语
出版者OXFORD UNIV PRESS INC
WOS记录号WOS:001048345100001
源URL[http://ir.ia.ac.cn/handle/173211/53975]  
专题脑图谱与类脑智能实验室
通讯作者Han, Shihui; Zhang, Yong Q.
作者单位1.Peking Univ, McGovern Inst Brain Res, Sch Psychol & Cognit Sci, PKU IDG,Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Liang,Mei, Shuting,Yu, Shan,et al. Shank3 mutations enhance early neural responses to deviant tones in dogs[J]. CEREBRAL CORTEX,2023:12.
APA Wu, Liang,Mei, Shuting,Yu, Shan,Han, Shihui,&Zhang, Yong Q..(2023).Shank3 mutations enhance early neural responses to deviant tones in dogs.CEREBRAL CORTEX,12.
MLA Wu, Liang,et al."Shank3 mutations enhance early neural responses to deviant tones in dogs".CEREBRAL CORTEX (2023):12.

入库方式： OAI收割

来源：自动化研究所

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