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The Effects of Low Dose Ketamine on Working Memory

文献类型：期刊论文

作者Zhao Zhi-Ping1,5; Nie Chuang2; Jiang Cheng-Teng6; Luo Wei-Wei2; Gu Jian-Wen2; Yu Shan3,4
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
出版日期2023-03-01
卷号50期号:3页码:473-485
ISSN号1000-3282
关键词low-dose ketamine working memory NMDA receptors acute effect chronic effect
DOI10.16476/j.pibb.2022.0195
通讯作者Gu Jian-Wen(jiuwufushou@qq.com) ; Yu Shan(shan.yu@nlpr.ia.ac.cn)
英文摘要Ketamine is an NMDAR antagonist that has been widely used for clinical anesthesia. In addition, low-dose ketamine has analgesic, anti-inflammatory and antidepressant effects, which have attracted extensive attention in recent years. However, how low-dose ketamine can affect the higher cognitive functions remain unclear. Here we review the effects of low-dose ketamine on working memory (WM). WM is the ability to temporally hold and manipulate information in the brain. It mainly relies on a network involving several key brain areas such as the prefrontal cortex (PFC), hippocampus, etc. WM plays a key role in many complex cognitive processes, thus to understand how it may be affected by low-dose ketamine is informative and important for its clinic use. Here we review the studies showing that acute or chronic use of low-dose ketamine will impair working memory in a sophisticated way. The possible mechanisms underlying such impairments include breaking the excitation/inhibition (E/I) balance in the PFC, changing the short-term and long-term synaptic plasticity, activating the DA pathway, etc. We also pointed out that to fully reveal the effects of low-dose ketamine on WM and related neural mechanism, future multi-facet studies combining behavioral tests, electrophysiology, neuroimaging, histology, etc, and with more comparable dosage and time of medication would be needed. We hope that this review will be instrumental for facilitating appropriate use of low-dose ketamine in clinical settings.
WOS关键词PREFRONTAL CORTEX ; ANTIDEPRESSANT ACTIONS ; COGNITIVE IMPAIRMENTS ; DOPAMINERGIC FUNCTION ; ANTAGONISTS KETAMINE ; NMDA RECEPTORS ; DEPRESSION ; INCREASES ; PROFILE ; MODEL
资助项目National Key Research and Development Program of China[2017YFA0105203] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32040200]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号WOS:001054480300005
资助机构National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/54131]  
专题脑图谱与类脑智能实验室
通讯作者Gu Jian-Wen; Yu Shan
作者单位1.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China
2.Strateg Support Force Med Ctr, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
6.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China
推荐引用方式
GB/T 7714		 Zhao Zhi-Ping,Nie Chuang,Jiang Cheng-Teng,et al. The Effects of Low Dose Ketamine on Working Memory[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2023,50(3):473-485.
APA Zhao Zhi-Ping,Nie Chuang,Jiang Cheng-Teng,Luo Wei-Wei,Gu Jian-Wen,&Yu Shan.(2023).The Effects of Low Dose Ketamine on Working Memory.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,50(3),473-485.
MLA Zhao Zhi-Ping,et al."The Effects of Low Dose Ketamine on Working Memory".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 50.3(2023):473-485.

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