Long-term cardiovascular outcomes of biodegradable polymer drug eluting stents in patients with diabetes versus non-diabetes mellitus: a meta-analysis
文献类型：期刊论文
| 作者 | Wang, Hong1; Zu, Quannan2 ; Tang, Hairong1; Lu, Ming2; Chen, Rongfa3; Yang, Zhiren3
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| 刊名 | CARDIOVASCULAR DIABETOLOGY
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| 出版日期 | 2023-08-29 |
| 卷号 | 22期号:1页码:10 |
| 关键词 | Biodegradable polymer drug eluting stents Durable polymer drug eluting stents Percutaneous coronary intervention Diabetes mellitus Cardiovascular diseases Stent thrombosis Revascularization |
| DOI | 10.1186/s12933-023-01962-w |
| 通讯作者 | Wang, Hong(iriswh2014@163.com) |
| 英文摘要 | BackgroundToday, diabetes mellitus (DM) has become a worldwide concern. DM is a major risk factor for the development of cardiovascular diseases (CVD). Eligible patients with CVD are treated invasively by percutaneous coronary intervention (PCI) whereby a stent is implanted inside the coronary vessel with the particular lesion to allow sufficient blood flow. Newer scientific research have shown that even though associated with a lower rate of re-stenosis, first-generation drug eluting stents (DES) were associated with a higher rate of late stent thrombosis. Recently, newer stents, namely biodegradable polymer DES (BP-DES) have been developed to overcome the safety issues of earlier generation DES. In this analysis we aimed to systematically compare the long term (& GE; 12 months) adverse cardiovascular outcomes observed in DM versus non-DM patients who were implanted with BP-DES.MethodsCochrane central, MEDLINE (Subset PubMed), EMBASE, Web of Science, http://www.ClinicalTrials.gov and Google scholar were searched for relevant publications involving BP-DES in patients with DM versus non-DM and their associated adverse cardiovascular outcomes. The mean follow-up time period ranged from 12 to 120 months. Data analysis was carried out with the latest version of the RevMan software (version 5.4). Based on the Mantel-Haenszel test, risk ratios (RR) with 95% confidence intervals (CI) were calculated and used to represent the results following analysis.ResultsSeven (7) studies with a total number of 10,246 participants were included in this analysis. Stents which were implanted during PCI were BP-DES. Participants were enrolled from the year 2006 to 2013. Our current results showed that in patients who were implanted with BP-DES, the risks of major adverse cardiac events (RR: 1.30, 95% CI: 1.18-1.43; P = 0.00001), myocardial infarction (RR: 1.48, 95% CI: 1.14-1.93; P = 0.003), all-cause mortality (RR: 1.70, 95% CI: 1.29-2.23; P = 0.0002), cardiac death (RR: 1.93, 95% CI: 1.28-2.93; P = 0.002), target vessel revascularization (RR: 1.35, 95% CI: 1.03-1.77; P = 0.03), target lesion revascularization (RR: 1.28, 95% CI: 1.07-1.54; P = 0.007) and target lesion failure (RR: 1.79, 95% CI: 1.52-2.12; P = 0.00001) were significantly higher in the DM group. Definite and probable stent thrombosis (RR: 1.80, 95% CI: 1.28-2.55; P = 0.0009) were also significantly higher in the DM group.ConclusionsDiabetes mellitus was an independent risk factor associated with long term adverse cardiovascular outcomes following PCI with BP-DES. |
| WOS关键词 | CORONARY-ARTERY-DISEASE ; THROMBOSIS ; EFFICACY ; SAFETY |
| 资助项目 | Not applicable. |
| WOS研究方向 | Cardiovascular System & Cardiology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | BMC |
| WOS记录号 | WOS:001057617700001 |
| 资助机构 | Not applicable. |
| 源URL | [http://ir.ia.ac.cn/handle/173211/54077]  |
| 专题 | 舆论大数据科学与技术应用联合实验室 |
| 通讯作者 | Wang, Hong |
| 作者单位 | 1.Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China 2.Tianjin Univ, Coll Management & Econ, Tianjin 300072, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hong,Zu, Quannan,Tang, Hairong,et al. Long-term cardiovascular outcomes of biodegradable polymer drug eluting stents in patients with diabetes versus non-diabetes mellitus: a meta-analysis[J]. CARDIOVASCULAR DIABETOLOGY,2023,22(1):10. |
| APA | Wang, Hong,Zu, Quannan,Tang, Hairong,Lu, Ming,Chen, Rongfa,&Yang, Zhiren.(2023).Long-term cardiovascular outcomes of biodegradable polymer drug eluting stents in patients with diabetes versus non-diabetes mellitus: a meta-analysis.CARDIOVASCULAR DIABETOLOGY,22(1),10. |
| MLA | Wang, Hong,et al."Long-term cardiovascular outcomes of biodegradable polymer drug eluting stents in patients with diabetes versus non-diabetes mellitus: a meta-analysis".CARDIOVASCULAR DIABETOLOGY 22.1(2023):10. |
入库方式： OAI收割
来源：自动化研究所
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