Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep
文献类型：期刊论文
| 作者 | Tian, Dehong; Sun, De; Ren, Qianben; Zhang, Pei; Zhang, Zian; Zhang, Wenkui; Luo, Haizhou; Li, Xue; Han, Buying; Liu, Dehui |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2023 |
| 卷号 | 13期号:1 |
| 英文摘要 | Copy number variation (CNV) is a genetic structural polymorphism important for phenotypic diversity and important economic traits of livestock breeds, and it plays an important role in the desired genetic variation. This study used whole genome sequencing to detect the CNV variation in the genome of 6 local Tibetan sheep groups. We detected 69,166 CNV events and 7230 copy number variable regions (CNVRs) after merging the overlapping CNVs, accounting for 2.72% of the reference genome. The CNVR length detected ranged from 1.1 to 1693.5 Kb, with a total length of 118.69 Mb and an average length of 16.42 Kb per CNVR. Functional GO cluster analysis showed that the CNVR genes were mainly involved in sensory perception systems, response to stimulus, and signal transduction. Through CNVR-based Vst analysis, we found that the CACNA2D3 and CTBP1 genes related to hypoxia adaptation, the HTR1A gene related to coat color, and the TRNAS-GGA and PIK3C3 genes related to body weight were all strongly selected. The findings of our study will contribute novel insights into the genetic structural variation underlying hypoxia adaptation and economically important traits in Tibetan sheep. |
| 源URL | [http://210.75.249.4/handle/363003/61558]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Tian, Dehong,Sun, De,Ren, Qianben,et al. Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep[J]. SCIENTIFIC REPORTS,2023,13(1). |
| APA | Tian, Dehong.,Sun, De.,Ren, Qianben.,Zhang, Pei.,Zhang, Zian.,...&Zhao, Kai.(2023).Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep.SCIENTIFIC REPORTS,13(1). |
| MLA | Tian, Dehong,et al."Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep".SCIENTIFIC REPORTS 13.1(2023). |
入库方式： OAI收割
来源：西北高原生物研究所
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