Single-cell transcriptomic characterization of sheep conceptus elongation and implantation
文献类型：期刊论文
| 作者 | Jia, Gong-Xue; Ma, Wen-Ji; Wu, Zhao-Bo; Li, Shuang; Zhang, Xiao-Qian; He, Zhen; Wu, Shi-Xin; Tao, Hai-Ping; Fang, Yi; Song, Yong-Wu |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2023 |
| 卷号 | 42期号:8 |
| 英文摘要 | Bidirectional communication between the developing conceptus and endometrium is essential for preg-nancy recognition and establishment in ruminants. We dissect the transcriptomic dynamics of sheep conceptus and corresponding endometrium at pre-and peri-implantation stages using single-cell RNA sequencing. Spherical blastocysts contain five cell types, with 68.62% trophectoderm cells. Strikingly, elongated conceptuses differentiate into 17 cell types, indicating dramatic cell fate specifications. Cell -type-specific gene expression delineates the features of distinctive trophectoderm lineages and indicates that the transition from polar trophectoderm to trophoblast increases interferon-tau expression and likely drives elongation initiation. We identify 13 endometrium-derived cell types and elucidate their molecular responses to conceptus development. Integrated analyses uncover multiple paired transcripts mediating the dialogues between extraembryonic membrane and endometrium, including IGF2-IGF1R, FGF19- FGFR1, NPY-NPY1R, PROS1-AXL, and ADGRE5-CD55. These data provide insight into the molecular regu-lation of conceptus elongation and represent a valuable resource for functional investigations of pre-and peri-implantation ruminant development. |
| 源URL | [http://210.75.249.4/handle/363003/61604]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Jia, Gong-Xue,Ma, Wen-Ji,Wu, Zhao-Bo,et al. Single-cell transcriptomic characterization of sheep conceptus elongation and implantation[J]. CELL REPORTS,2023,42(8). |
| APA | Jia, Gong-Xue.,Ma, Wen-Ji.,Wu, Zhao-Bo.,Li, Shuang.,Zhang, Xiao-Qian.,...&Yang, Qi-En.(2023).Single-cell transcriptomic characterization of sheep conceptus elongation and implantation.CELL REPORTS,42(8). |
| MLA | Jia, Gong-Xue,et al."Single-cell transcriptomic characterization of sheep conceptus elongation and implantation".CELL REPORTS 42.8(2023). |
入库方式： OAI收割
来源：西北高原生物研究所
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