Event-related potentials reveal visual episodic memory deficits in patients with temporal lobe epilepsy
文献类型:期刊论文
作者 | Tian, Ziwei4,5,6; Huang, Sha2,3; Wen, Shirui2,3; Zhang, Qiong2,3; Huang, Kailing2,3; Gui, Yawei4,5,6; Hu, Bingliang4,6; Feng, Li1,2,3; Wang, Quan4,6 |
刊名 | EPILEPSY & BEHAVIOR |
出版日期 | 2023-11 |
卷号 | 148 |
ISSN号 | 1525-5050;1525-5069 |
关键词 | Temporal lobe epilepsy Episodic memory ERP FN400 LPC LPN |
DOI | 10.1016/j.yebeh.2023.109460 |
产权排序 | 1 |
英文摘要 | Objective: Temporal lobe epilepsy (TLE) patients usually suffer from impaired episodic memory (EM), but its underlying electrophysiologic mechanism and impacted cognitive performance are unclear. We aim to investigate the association between episodic memory reserve and physiological measures of memory workload in TLE patients using Event-related potentials (ERP).Methods: A change detection task with image stimuli assesses visual episodic memory. During the memory encoding and decoding phases, the ERP signals were analyzed from twenty-nine TLE patients (twelve with left TLE patients, seventeen with TLE), and thirty healthy controls. Given that EM is a complex pro-cess involving many fundamental cognitive processes, the amplitudes and latencies of EM-related ERP (FN400, late positive potential (LPC), and late posterior negativity (LPN)), and the ERP reflecting the fundamental processes (P100, N100, P200, and P300) were calculated. Then we used a three-by-two factorial design on the ERP metrics for interaction and main effects. The correlation analysis among Wechsler Memory Scales-Chinese Revision (WMS-RC) results, behavioral data, and the ERPs was carried out.Results: The TLE patients performed worse in WMS-RC and the memory task. The increased P200 and decreased P300 amplitudes were observed in the TLE patients, and LPN was abnormal in only LTLE patients. For EM-related components, differences were observed in both the LTLE and RTLE patients: the lack of the FN400 effect, the lack of the reversed LPC effect, and the reduced FN400. No significant inter-group difference was detected for the latencies of all the ERPs. Additionally, there were significant correlations among WMS-RC scores, behaviors, and some ERP amplitudes.Conclusions: The impaired EM is linked to the increased P200 and decreased P300 amplitudes. LPN seems to be sensitive to left temporal lobe dysfunction. More importantly, the abnormal old or new effects of the FN400 and LPC, and the reduced FN400 amplitude might be associated with the visual EM deficit in the TLE patients. These findings may assist in the deep understanding of the EM disorder and the evaluation of the side effects of antiepileptic drugs. (c) 2023 Elsevier Inc. All rights reserved. |
语种 | 英语 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS记录号 | WOS:001098494300001 |
源URL | [http://ir.opt.ac.cn/handle/181661/97022] |
专题 | 西安光学精密机械研究所_光学影像学习与分析中心 |
通讯作者 | Feng, Li; Wang, Quan |
作者单位 | 1.Cent South Univ, Xiangya Hosp, Dept Neurol, Jiangxi Branch, Nanchang, Jiangxi, Peoples R China 2.Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 330000, Hunan, Peoples R China 3.Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China 4.Chinese Acad Sci, Xian Inst Opt & Precis Mech, Key Lab Spectral Imaging Technol, Xian 710119, Peoples R China 5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 6.Chinese Acad Sci, Xian Inst Opt & Precis Mech, Xian 710119, Peoples R China |
推荐引用方式 GB/T 7714 | Tian, Ziwei,Huang, Sha,Wen, Shirui,et al. Event-related potentials reveal visual episodic memory deficits in patients with temporal lobe epilepsy[J]. EPILEPSY & BEHAVIOR,2023,148. |
APA | Tian, Ziwei.,Huang, Sha.,Wen, Shirui.,Zhang, Qiong.,Huang, Kailing.,...&Wang, Quan.(2023).Event-related potentials reveal visual episodic memory deficits in patients with temporal lobe epilepsy.EPILEPSY & BEHAVIOR,148. |
MLA | Tian, Ziwei,et al."Event-related potentials reveal visual episodic memory deficits in patients with temporal lobe epilepsy".EPILEPSY & BEHAVIOR 148(2023). |
入库方式: OAI收割
来源:西安光学精密机械研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。