Towards interpretable imaging genomics analysis: Methodological developments and applications
文献类型：期刊论文
| 作者 | Cen, Xiaoping2,3,4; Dong, Wei4,6,15; Lv, Wei2,4; Zhao, Yi8; Dubee, Fred7; Mentis, Alexios-Fotios A.6; Jovic, Dragomirka7; Yang, Huanming1,2,4,5; Li, Yixue3,9,10,11,12,13,14 |
| 刊名 | INFORMATION FUSION
 |
| 出版日期 | 2024-02-01 |
| 卷号 | 102页码:18 |
| 关键词 | Interpretability Imaging genomics Genotype -phenotype association Precision medicine |
| ISSN号 | 1566-2535 |
| DOI | 10.1016/j.inffus.2023.102032 |
| 英文摘要 | Identifying the relationship between imaging features and genetic variation (a term coined"imaging genomics") offers valuable insight into the pathogenesis of cancer, as well as cognitive and psychiatric disorders. However, how to integrate-omics and imaging data in a biologically meaningful approach to both provide pathobiological underpinning and achieve clinical applications remain challenging. In this review, we aim to discuss the difficulties in combining different sources of data and explaining the genotype-phenotype association, and we attempt to discuss the potential applications of imaging genomics in several (patho)physiological questions to better understand human physiology and disease. Future efforts on deciphering the genotype-phenotype landscapes by interpretable imaging genomics analyses are needed to provide new insights into molecular biology and molecular medicine. |
| 资助项目 | CAS Research Fund[XDB38050200] ; Self-supporting Program of Guangzhou Laboratory[SRPG22-001] ; Self-supporting Program of Guangzhou Laboratory[SRPG22-007] |
| WOS研究方向 | Computer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001083203700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/21113]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Yang, Huanming; Li, Yixue |
| 作者单位 | 1.James D Watson Inst Genome Sci, Hangzhou 310029, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 3.Guangzhou Int Bio Isl, Guangzhou Lab, 9 XingDaoHuanBei Rd, Guangzhou 510005, Peoples R China 4.Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, HIM BGI Om Ctr, Hangzhou 310022, Peoples R China 5.BGI China, Shenzhen 518083, Peoples R China 6.BGI Res, Shenzhen 518083, Peoples R China 7.BGI Res, Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, Qingdao 266555, Peoples R China 8.Chinese Acad Sci, Inst Comp Technol, Res Ctr Ubiquitous Comp Syst, Beijing 100190, Peoples R China 9.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China 10.Guangzhou Med Univ, GMU GIBH Joint Sch Life Sci, Guangdong Hong Kong Macao Joint Lab Cell Fate Regu, Hong Kong 510120, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cen, Xiaoping,Dong, Wei,Lv, Wei,et al. Towards interpretable imaging genomics analysis: Methodological developments and applications[J]. INFORMATION FUSION,2024,102:18. |
| APA | Cen, Xiaoping.,Dong, Wei.,Lv, Wei.,Zhao, Yi.,Dubee, Fred.,...&Li, Yixue.(2024).Towards interpretable imaging genomics analysis: Methodological developments and applications.INFORMATION FUSION,102,18. |
| MLA | Cen, Xiaoping,et al."Towards interpretable imaging genomics analysis: Methodological developments and applications".INFORMATION FUSION 102(2024):18. |
入库方式： OAI收割
来源：计算技术研究所
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