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Stress can affect mitochondrial energy metabolism and AMPK/SIRT1 signaling pathway in rats

文献类型：期刊论文

作者Zhao, An-ran4,5; Li, Jie4,5; Wang, Si-qi4,5; Bian, Li-hua3,4; Li, Wen-jing4,5; Guo, Jian-you1,2,4,5
刊名BRAIN RESEARCH BULLETIN
出版日期2023-10-15
卷号203页码:9
ISSN号0361-9230
关键词Anxiety Mitochondrial function Energy metabolism AMPK/SIRT1 pathways
DOI10.1016/j.brainresbull.2023.110770
通讯作者Guo, Jian-you(guojy@psych.ac.cn)
英文摘要Objection: To investigate the potential link between aberrant mitochondrial energy metabolism mediated by the AMPK/SIRT1 pathway and the etiology of anxiety disorders.Methods: The anxiety rat model was established by uncertain empty water bottle(UEWB)stress. Rats were submitted behavioral tests on the seventh, fourteenth, and twenty-first days and had the prefrontal cortex and amygdala removed for biochemical tests. The morphological alterations of the mitochondria in the medial prefrontal cortex and amygdala were examined by using a transmission electron microscope. Expression levels of AMPK, SIRT1, PGC-1, NRF-1 and NRF-2 were tested by western-blot analysis. ATP, respiratory chain complex and caspase enzyme expressions were tested by neurochemical and biochemical assays. Results: Rats showed anxiety-like behavior after being exposed to the uncertain empty water bottle (UEWB) stress model. In model rats, mitochondrial structure is damaged, mitochondrial energy metabolism is decreased, and the expression of proteins associated with AMPK/SIRT1 pathway is significantly reduced in the brain. Conclusion: The level of mitochondrial energy metabolism correlates with anxiety-like behavior. The main mechanism of anxiety disorder is a disturbance of mitochondrial energy metabolism, which might be related to AMPK/SIRT1 pathway.
收录类别SCI
WOS关键词ACTIVATED PROTEIN-KINASE ; ANXIETY ; DYSFUNCTION ; MODULATION ; DEPRESSION ; BEHAVIORS ; APOPTOSIS ; AUTOPHAGY ; CASPASES ; SUPPORT
资助项目Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX] ; Open Research Fund of Collegeof Teacher Education, Zhejiang Normal University[jykf22011]
WOS研究方向Neurosciences & Neurology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:001089652400001
资助机构Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Open Research Fund of Collegeof Teacher Education, Zhejiang Normal University
源URL[http://ir.psych.ac.cn/handle/311026/46305]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Guo, Jian-you
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Zhejiang Normal Univ, Key Lab Intelligent Educ Technol & Applicat Zhejia, Jinhua 321004, Zhejiang, Peoples R China
3.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, An-ran,Li, Jie,Wang, Si-qi,et al. Stress can affect mitochondrial energy metabolism and AMPK/SIRT1 signaling pathway in rats[J]. BRAIN RESEARCH BULLETIN,2023,203:9.
APA Zhao, An-ran,Li, Jie,Wang, Si-qi,Bian, Li-hua,Li, Wen-jing,&Guo, Jian-you.(2023).Stress can affect mitochondrial energy metabolism and AMPK/SIRT1 signaling pathway in rats.BRAIN RESEARCH BULLETIN,203,9.
MLA Zhao, An-ran,et al."Stress can affect mitochondrial energy metabolism and AMPK/SIRT1 signaling pathway in rats".BRAIN RESEARCH BULLETIN 203(2023):9.

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来源：心理研究所

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