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Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety

文献类型：期刊论文

作者Ye, Gang4,5; Yuan, Ying4; Li, Zhe4; Yue, Yan4,5; Wu, Yuxuan4,5; Yang, Ruchang4,5; Wang, Haitao3; Wu, Siqi3,4; Zhou, Yue2,4; Zhao, Xueli4
刊名SCIENTIFIC REPORTS
出版日期2023-08-22
卷号13期号:1页码:9
ISSN号2045-2322
DOI10.1038/s41598-023-40948-2
通讯作者Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要This study aimed to explore sex differences in the relationship between thyroid function indicators and suicide attempts in first-episode and drug-naive young major depressive disorder (MDD) patients with comorbid anxiety (MDA). A total of 917 MDD patients (aged 18-35 years) were recruited. The Hamilton depression rating scale (HAMD-17), Hamilton anxiety rating scale (HAMA), positive and negative syndrome scale (PANSS) positive subscale and clinical global impression of severity scale (CGI-S) were used. 467 patients were classified as MDA. The prevalence of suicide attempts was 31.3% in MDA patients, which was significantly higher than that (7.3%) in MDD patients without anxiety. Compared with MDA patients without suicide attempts, MDA patients with suicide attempts were older, had a later age of onset, higher HAMD-17, HAMA, and PANSS positive symptom subscale scores, as well as higher TSH, TgAb and TPOAb levels. For male patients, TSH and TPOAb levels were independently associated with suicide attempts. For female patients, HAMA, PANSS positive symptom scores, CGI-S score and TPOAb levels were independently associated with suicide attempts. Our results suggest that the indicators of thyroid function which can predict suicide attempts in male and female MDA patients have sex differences.
收录类别SCI
WOS关键词GENDER DIFFERENCES ; RISK-FACTORS ; ADOLESCENTS ; IDEATION ; INDIVIDUALS ; PREVALENCE ; BEHAVIORS ; ADULTS
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001052937600052
出版者NATURE PORTFOLIO
源URL[http://ir.psych.ac.cn/handle/311026/46329]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Du, Xiangdong; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Xuzhou Med Univ, Xuzhou, Peoples R China
3.North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Tangshan, Peoples R China
4.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China
5.Soochow Univ, Suzhou Med Coll, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Gang,Yuan, Ying,Li, Zhe,et al. Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety[J]. SCIENTIFIC REPORTS,2023,13(1):9.
APA Ye, Gang.,Yuan, Ying.,Li, Zhe.,Yue, Yan.,Wu, Yuxuan.,...&Zhang, Xiangyang.(2023).Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety.SCIENTIFIC REPORTS,13(1),9.
MLA Ye, Gang,et al."Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety".SCIENTIFIC REPORTS 13.1(2023):9.

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来源：心理研究所

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