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Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder

文献类型：期刊论文

作者Shang, ZhaoXuan2; Lang, XiaoE1; Wang, Jikun2; Zhang, XiangYang3
刊名EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
出版日期2023-10-25
页码10
关键词Major depressive disorder Psychotic symptoms Suicide attempts Prevalence Risk factors
ISSN号0940-1334
DOI10.1007/s00406-023-01698-4
通讯作者Wang, Jikun(jkwang@psy.ecnu.edu.cn) ; Zhang, XiangYang(zhangxy@psych.ac.cn)
英文摘要This study investigates the relationship between psychotic symptoms and suicide attempts in young first-episode, drug-naive Chinese Han outpatients diagnosed with Major Depressive Disorder (MDD). The prevalence of Psychotic Major Depressive Disorder (PMD) was found to be 8.3% among the enrolled MDD patients. The study assessed 1289 participants using various scales to evaluate the severity of clinical symptoms, including the CGI-S, the HAMD, the HAMA, and the PANSS positive subscale. Additionally, thyroid hormone and glucolipid metabolism indicators were examined. The findings indicate that among patients with PMD, 41.12% had recent suicide attempts, while 6.54% had previous suicide attempts. Patients who recently attempted suicide exhibited higher scores on the HAMA and CGI scales, along with elevated serum levels of Thyroid-Stimulating Hormone (TSH) and total cholesterol (TC), as well as higher systolic and diastolic blood pressure. Notably, TSH levels independently correlated with recent suicide attempts in PMD patients, with an impressive area under the receiver operating characteristic curve (AUROC) of 0.923. Furthermore, the subgroup of patients with previous suicide attempts displayed longer illness duration and higher HAMD scores. Duration of illness and HAMD were found to be independently associated with previous suicide attempts among PMD patients, with a combined predictive effect showing a robust AUROC of 0.910. In conclusion, this study highlights the significant prevalence of recent and previous suicide attempts among young Chinese Han outpatients with PMD. The identification of risk factors, especially the link between TSH levels and recent suicide attempts, offers valuable insights for clinicians to develop targeted interventions and preventive strategies for this vulnerable patient population.
收录类别SCI
WOS关键词DELUSIONAL DEPRESSION ; THYROID-DYSFUNCTION ; EXPERIENCES ; IDEATION ; INDIVIDUALS ; THYROTROPIN ; ASSOCIATION ; DIAGNOSIS ; SYMPTOMS
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001086821700001
出版者SPRINGER HEIDELBERG
源URL[http://ir.psych.ac.cn/handle/311026/46335]  
专题心理研究所_中国科学院心理健康重点实验室
心理研究所_健康与遗传心理学研究室
通讯作者Wang, Jikun; Zhang, XiangYang
作者单位1.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China
2.East China Normal Univ, Dept Psychol & Cognit Sci, Shanghai, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Shang, ZhaoXuan,Lang, XiaoE,Wang, Jikun,et al. Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023:10.
APA Shang, ZhaoXuan,Lang, XiaoE,Wang, Jikun,&Zhang, XiangYang.(2023).Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,10.
MLA Shang, ZhaoXuan,et al."Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023):10.

入库方式： OAI收割

来源：心理研究所

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