中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Unlocking the link: how hippocampal glutathione-glutamate coupling predicts cognitive impairment in multiple sclerosis patients

文献类型：期刊论文

作者Li, Fuyan9; Zong, Wei9; Xin, Chenxi8; Ren, Fuxin7,9; Li, Ning9; Li, Honghao6; Li, Xiao7,9; Wu, Lili5; Dai, Zongrui4; Chen, Weibo3
刊名CEREBRAL CORTEX
出版日期2023-11-06
页码11
关键词cognitive impairment glutamate glutathione magnetic resonance spectroscopy relapsing-remitting multiple sclerosis
ISSN号1047-3211
DOI10.1093/cercor/bhad400
通讯作者Gao, Fei(feigao@email.sdu.edu.cn) ; Wang, Guangbin(wgb7932596@hotmail.com)
英文摘要Cognitive impairment is a common symptom of multiple sclerosis and profoundly impacts quality of life. Glutathione (GSH) and glutamate (Glu) are tightly linked in the brain, participating in cognitive function. However, GSH-Glu couplings in cognitive brain regions and their relationship with cognitive impairment in relapsing-remitting multiple sclerosis (RRMS) remains unclear. Forty-one RRMS patients and 43 healthy controls underwent magnetic resonance spectroscopy to measure GSH and Glu levels in the posterior cingulate cortex, medial prefrontal cortex and left hippocampus. Neuropsychological tests were used to evaluate the cognitive function. The Glu/GSH ratio was used to indicate the coupling between GSH and Glu and was tested as a predictor of cognitive performance. The results show that RRMS patients exhibited reduced hippocampal GSH and Glu levels, which were found to be significant predictors of worse verbal and visuospatial memory, respectively. Moreover, GSH levels were dissociated from Glu levels in the left hippocampus of RRMS patients. Hippocampal Glu/GSH ratio is significantly correlated with processing speed and has a greater predictive effect. Here we show the hippocampal Glu/GSH ratio could serve as a new potential marker for characterizing cognitive impairment in RRMS, providing a new direction for clinical detection of cognitive impairment.
收录类别SCI
WOS关键词BRAIN ; INSIGHTS ; DEFICITS ; RELEASE ; STRESS ; MRI
资助项目The authors are grateful for the technical assistance provided by Liangjie Lin from Philips Healthcare. ; Philips Healthcare
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001097662300001
出版者OXFORD UNIV PRESS INC
资助机构The authors are grateful for the technical assistance provided by Liangjie Lin from Philips Healthcare. ; Philips Healthcare
源URL[http://ir.psych.ac.cn/handle/311026/46374]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Gao, Fei; Wang, Guangbin
作者单位1.Shandong First Med Univ, Shandong Prov Hosp, Dept Radiol, Jingwu Rd 324, Jinan 250021, Peoples R China
2.Vanderbilt Univ, Vanderbilt Univ Inst Imaging Sci, Med Ctr, 1161 21st Ave S,Med Ctr North,AA 1105, Nashville, TN 37232 USA
3.Philips Healthcare, Bldg 718,Lingshi Rd, Shanghai 200072, Peoples R China
4.Univ Michigan, Dept Biostat, 500 S State St, Ann Arbor, MI 48109 USA
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
6.Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jing Wu Rd 324, Jinan 250021, Peoples R China
7.Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Radiol, Jing Wu Rd 324, Jinan, Peoples R China
8.Xinxiang Med Univ, Sch Int Educ, 601 Jinsui Ave, Xinxiang 453003, Peoples R China
9.Shandong First Med Univ, Shandong Prov Hosp, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Minist Educ,Dept Radiol, Jing Wu Rd 324, Jinan 250021, Peoples R China
推荐引用方式
GB/T 7714		 Li, Fuyan,Zong, Wei,Xin, Chenxi,et al. Unlocking the link: how hippocampal glutathione-glutamate coupling predicts cognitive impairment in multiple sclerosis patients[J]. CEREBRAL CORTEX,2023:11.
APA Li, Fuyan.,Zong, Wei.,Xin, Chenxi.,Ren, Fuxin.,Li, Ning.,...&Wang, Guangbin.(2023).Unlocking the link: how hippocampal glutathione-glutamate coupling predicts cognitive impairment in multiple sclerosis patients.CEREBRAL CORTEX,11.
MLA Li, Fuyan,et al."Unlocking the link: how hippocampal glutathione-glutamate coupling predicts cognitive impairment in multiple sclerosis patients".CEREBRAL CORTEX (2023):11.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。