Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population
文献类型：期刊论文
| 作者 | Xue, Hui24,25; Xu, Xiaojun23; Yan, Zhihan21,22; Cheng, Jingliang20; Zhang, Longjiang19; Zhu, Wenzhen18; Cui, Guangbin16,17; Zhang, Quan15 ; Qiu, Shijun14; Yao, Zhenwei13
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| 刊名 | ISCIENCE
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| 出版日期 | 2023-10-20 |
| 卷号 | 26期号:10页码:16 |
| DOI | 10.1016/j.isci.2023.108005 |
| 通讯作者 | Yu, Yongqiang(yuyongqiang@ahmu.edu.cn) ; Xian, Junfang(cjr.xianjunfang@vip.163.com) ; Yu, Chunshui(chunshuiyu@tmu.edu.cn) |
| 英文摘要 | Correlation between blood-oxygen-level-dependent (BOLD) and cerebral blood flow (CBF) has been used as an index of neurovascular coupling. Hippocampal BOLD-CBF correlation is associated with neurocognition, and the reduced correlation is associated with neuropsychiatric disorders. We conducted the first genome-wide association study of the hippocampal BOLD-CBF correlation in 4,832 Chinese Han subjects. The hippocampal BOLD-CBF correlation had an estimated heritability of 16.2-23.9% and showed reliable genome-wide significant association with a locus at 3q28, in which many variants have been linked to neuroimaging and cerebrospinal fluid markers of Alzheimer's disease. Gene-based association analyses showed four significant genes (GMNC, CRTC2, DENND4B, and GATAD2B) and revealed enrichment for mast cell calcium mobilization, microglial cell proliferation, and ubiquitin-related proteolysis pathways that regulate different cellular components of the neurovascular unit. This is the first unbiased identification of the association of hippocampal BOLD-CBF correlation, providing fresh insights into the genetic architecture of hippocampal neurovascular coupling. |
| 收录类别 | SCI |
| WOS关键词 | ACCESSORY PROTEIN P56 ; BRAIN ; DISEASE ; SYSTEM ; FMRI ; NEUROGENESIS ; VARIANTS ; MEMORY ; BOLD |
| 资助项目 | National Key Research and Development Program of China[2018YFC1314300] ; National Natural Science Foundation of China[82030053] ; National Natural Science Foundation of China[81425013] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:001087019800001 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46344]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 通讯作者 | Yu, Yongqiang; Xian, Junfang; Yu, Chunshui |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 2.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China 3.Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei 230022, Peoples R China 4.Tianjin Med Univ, Key Lab Canc Prevent & Therapy, Tianjins Clin Res Ctr Canc,Minist Educ, Dept Radiol,Natl Clin Res Ctr Canc,Tianjin Med Un, Tianjin 300060, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 6.Beijing Normal Univ, McGovern Inst Brain Res, Dev Populat Neurosci Res Ctr IDG, Beijing 100875, Peoples R China 7.Xuzhou Med Univ, Affiliated Hosp, Dept Radiol, Xuzhou 221006, Peoples R China 8.Univ Sci & Technol China, Div Life Sci & Med, Hefei 230027, Peoples R China 9.Tianjin First Ctr Hosp, Dept Radiol, Tianjin 300192, Peoples R China 10.Tianjin Med Univ Canc Inst & Hosp, Dept Radiol, Tianjin 300060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Hui,Xu, Xiaojun,Yan, Zhihan,et al. Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population[J]. ISCIENCE,2023,26(10):16. |
| APA | Xue, Hui.,Xu, Xiaojun.,Yan, Zhihan.,Cheng, Jingliang.,Zhang, Longjiang.,...&Yu, Chunshui.(2023).Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population.ISCIENCE,26(10),16. |
| MLA | Xue, Hui,et al."Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population".ISCIENCE 26.10(2023):16. |
入库方式： OAI收割
来源：心理研究所
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