Objective: To explore the difference between the intrinsic; motivation of patients with depression and normal controls. Methods: Thirty patients with depression of patients with depression Statistical Manual of Mental Disorder, Fifth Edition(DSM-5) and 30 normal controls were included. The symptoms of depression and anxiety were assessed with the Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale HAMA) and the motivation was assessed with the motivational pleasure deficit subscale of Temporal Experience of Pleasure Scale(TEPS-ant). The independent choice paradigm was used to reflect the level of individual motivation by evaluating the memory performance under different choices. The relationship between the change of intrinsic motivation and clinical characteristics of patients with depression was analyzed. Results: The difference value of correct rate was lower in the depression group than in the normal control [(0.02士0. 09) vs. (0. 07士0. 08)，P<0.05]. There was no significant difference in the correct rate between selective and no-elective condition in the de pression group [(0.64士0.14) vs. (0. 62士0. 14) , P>0. 05] . In normal controls，the correct rate was higher in the selective condition than in the no-selection condition[(0.74士0.10) vs. (0.67士0.14) ,P<0. 001] . The difference value of correct rate in the patient group was positively correlated with TEPS-ant scores (r=0.67 ,P<0.05 ) and negatively correlated with HAMD scores (r=-0.42,P<0.05) . Conclusion: This study suggests that patients with depression have impaired intrinsic motivation, which is associated with severe depressive symptoms.

目的:探索抑郁症患者内在动机与正常对照间的差异.方法:纳入符合精神障碍诊断与统计手册第5版(DSM-5)抑郁症诊断标准的患者和正常对照各30例.用汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)评估患者的抑郁、焦虑程度,用愉快情绪体验量表中动机性快感缺失子量表(TEPS-ant)评估两组的动机.采用无关选择范式通过评估受试者在有选择和无选择两种条件下的记忆正确率,反映个体内在动机的水平.分析抑郁症患者内在动机的改变与临床特征之间的关联.结果:抑郁症组正确率的差值低于正常对照组[(0.02±0.09)vs.(0.07±0.08),P＜0.05].抑郁症组在选择情况和非选择情况下正确率的差异无统计学意义[(0.64±0.14)vs.(0.62±0.14),P＞0.05],正常对照组在选择情况下的正确率高于非选择时[(0.74±0.10)vs.(0.67±0.14),P＜0.001].抑郁症组正确率的差值与TEPS-ant总分(r=0.67,P＜0.05)呈正相关,与HAMD总分(r=-0.42,P＜0.05)负相关.结论:本研究提示抑郁症患者内在动机受损,患者内在动机受损与较重抑郁症状相关.