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A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides

文献类型：期刊论文

作者Zhang, Fan-Zhong1,2; Li, Xiao-Ming1,2; Meng, Ling-Hong1,2,3,4; Wang, Bin-Gui1,2,3,4
刊名JOURNAL OF ANTIBIOTICS
出版日期2023-10-26
页码8
ISSN号0021-8820
DOI10.1038/s41429-023-00666-3
通讯作者Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要Three new compounds, including one steroid named penivariod A (1) and two polyketides penivarides A and B (2 and 3), as well as six known derivatives (4-9) were isolated from Penicillium variabile EN-394, a fungus afforded from the marine red alga Rhodomela confervoides. Their structures were elucidated by analysis of the HRESIMS, 1D and 2D NMR. The absolute stereochemistry was determined by X-ray crystallographic data, gauge-independent atomic orbital (GIAO) NMR shift calculation followed by DP4+ analysis combined with calculated electronic circular dichroism (ECD). Antimicrobial activities for the new compounds (1-3) were evaluated against human-and aquatic-pathogenic bacteria as well as plant pathogenic fungi. Compound 1 exhibited potent antimicrobial activity against most of the pathogenic strains, especially for Escherichia coli and Pseudomonas aeruginosa, with MIC values of 1.0 and 2.0 mu g ml(-1), respectively.
WOS关键词A-D ; ASPERGILLUS
资助项目Financial support from the National Natural Science Foundation of China (31600267 and 42176115) and from the Natural Science Foundation of Jiangsu Province (No. BK20201211) is gratefully acknowledged.[31600267] ; Financial support from the National Natural Science Foundation of China (31600267 and 42176115) and from the Natural Science Foundation of Jiangsu Province (No. BK20201211) is gratefully acknowledged.[42176115] ; National Natural Science Foundation of China[BK20201211] ; Natural Science Foundation of Jiangsu Province
WOS研究方向Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001089669800001
出版者SPRINGERNATURE
源URL[http://ir.qdio.ac.cn/handle/337002/181558]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Meng, Ling-Hong; Wang, Bin-Gui
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
4.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,et al. A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides[J]. JOURNAL OF ANTIBIOTICS,2023:8.
APA Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,&Wang, Bin-Gui.(2023).A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides.JOURNAL OF ANTIBIOTICS,8.
MLA Zhang, Fan-Zhong,et al."A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides".JOURNAL OF ANTIBIOTICS (2023):8.

入库方式： OAI收割

来源：海洋研究所

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