Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
文献类型：期刊论文
| 作者 | Wang, Ying1,2 ; Ying, Zhen1,2; Li, Xiao-Ming1; Yang, Sui-Qun1; Li, Hong-Lei1; Wang, Bin-Gui1,2,3; Meng, Ling-Hong1,2
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| 刊名 | JOURNAL OF ANTIBIOTICS
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| 出版日期 | 2023-10-17 |
| 页码 | 7 |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/s41429-023-00664-5 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (3), together with a known nonadride analogue (4), were characterized from the Magellan Seamount-derived fungus Talaromyces scorteus AS-242. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. X-ray crystallographic analysis of compounds 1 and 3 confirmed their structures and absolute configurations, representing the first characterized crystal structure of a nonadride-type polyketide. The isolated compounds exhibited potent antimicrobial activities against the pathogenic bacterium MRSA and V. parahaemolyticus and pathogenic fungi C. gloeosporioides, F. oxysporum, and F. proliferatum, with MIC values ranging from 1 to 64 mu g ml(-1). |
| 资助项目 | National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Jiangsu Province[BK20201211] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | SPRINGERNATURE |
| WOS记录号 | WOS:001090950000001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/181573]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Meng, Ling-Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ying,Ying, Zhen,Li, Xiao-Ming,et al. Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242[J]. JOURNAL OF ANTIBIOTICS,2023:7. |
| APA | Wang, Ying.,Ying, Zhen.,Li, Xiao-Ming.,Yang, Sui-Qun.,Li, Hong-Lei.,...&Meng, Ling-Hong.(2023).Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242.JOURNAL OF ANTIBIOTICS,7. |
| MLA | Wang, Ying,et al."Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242".JOURNAL OF ANTIBIOTICS (2023):7. |
入库方式： OAI收割
来源：海洋研究所
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