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Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing

文献类型：期刊论文

作者Liu, Yang1,2,3; Deng, Zhenzhen1,2,4; Zhang, Jingjing5; Wu, Yumeng1,2,4; Wu, Ning1,2; Geng, Lihua1,2,4; Yue, Yang1,2,4; Zhang, Quanbin1,2,4; Wang, Jing1,2,4
刊名BIOMACROMOLECULES
出版日期2023-09-07
页码12
ISSN号1525-7797
DOI10.1021/acs.biomac.3c00569
通讯作者Wang, Jing(jingwang@qdio.ac.cn)
英文摘要A diabetic foot ulcer is a common high-risk complication in diabetic patients, but there is still no universal dressing for clinical treatment. In this study, a novel dual-functional sulfated galactofucan polysaccharide/poly(vinyl alcohol) hydrogel (DPH20) is developed during freeze-thaw cycles. Experimental results indicated that DPH20 had a high specific surface area, a dense porous structure, and a good swelling property, which could effectively adsorb the exudates and keep the wound moist. Furthermore, DPH20 exhibited remarkably recruited macrophage capability and accelerated the inflammation stage by improving the expression of the mRNA of CCL2, CCR2, and CCL22 in macrophages. DPH20 could promote cell migration and growth factor release to accelerate tube formation under hyperglycemic conditions in cell models of L929s and HUEVCs, respectively. Significantly, DPH20 accelerates the reconstruction of the full-thickness skin wound by accelerating the recruitment of macrophages, promoting angiogenesis, and releasing the growth factor in the diabetic mouse model. Collectively, DPH20 is a promising multifunctional dressing to reshape the damaged tissue environment and accelerate wound healing. This study provides an efficient strategy to repair and regenerate diabetic skin ulcers.
WOS关键词FUCOIDAN ; INJURY
资助项目Natural Science Foundation of China (NSFC)[41406144] ; Shandong Provincial Natural Science Foundation[ZR2022MD007] ; Science and Technology project of Fujian Province[2022T3024]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001066576000001
源URL[http://ir.qdio.ac.cn/handle/337002/181664]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Jing
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Qingdao Univ, Coll Mat Sci & Engn, Qingdao 266003, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
5.Qingdao Eighth Peoples Hosp, Qingdao 266121, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yang,Deng, Zhenzhen,Zhang, Jingjing,et al. Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing[J]. BIOMACROMOLECULES,2023:12.
APA Liu, Yang.,Deng, Zhenzhen.,Zhang, Jingjing.,Wu, Yumeng.,Wu, Ning.,...&Wang, Jing.(2023).Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing.BIOMACROMOLECULES,12.
MLA Liu, Yang,et al."Preparation of a Dual-Functional Sulfated Galactofucan Polysaccharide/Poly(vinyl alcohol) Hydrogel to Promote Macrophage Recruitment and Angiogenic Potential in Diabetic Wound Healing".BIOMACROMOLECULES (2023):12.

入库方式： OAI收割

来源：海洋研究所

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