Therapeutic potential of enzymatically extracted eumelanin from squid ink in type 2 diabetes mellitus ICR mice: Multifaceted intervention against hyperglycemia, oxidative stress and depression
文献类型：期刊论文
| 作者 | Song, Wen3,4,5,6; Xing, Ronge1,2,3,4,5 ; Yang, Haoyue3,4; Liu, Song3,4,5; Yu, Huahua3,4,5; Li, Pengcheng3,4,5
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| 刊名 | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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| 出版日期 | 2023-09-29 |
| 页码 | 15 |
| ISSN号 | 0022-5142 |
| 关键词 | type 2 diabetes mellitus (T2DM) eumelanin hypoglycemic activity antioxidant activity antidepressant activity |
| DOI | 10.1002/jsfa.12986 |
| 通讯作者 | Xing, Ronge(xingronge@qdio.ac.cn) |
| 英文摘要 | Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that poses significant health risks due to its numerous complications. However, the effects of eumelanin on oxidative stress, hyperglycemia and depression in diabetic mice have not been extensively studied. Results: Our study employed an enzymatic approach to extract eumelanin from squid ink and characterized it using spectroscopic techniques. Remarkably, eumelanin extracted with alkaline-neutral-flavor protease (ANF) displayed superior inhibitory activity against alpha-glucosidase and alpha-amylase, while enhancing glucose utilization and hepatic glycogen synthesis in human hepatocellular carcinoma cell line (HepG2) insulin resistance model. Further evaluation of ANF in a T2DM ICR mouse model demonstrated its significant potential in alleviating hyperglycemia, reducing glycosylated serum protein levels, improving glucose tolerance and modulating total cholesterol and low-density lipoprotein levels, as well as antioxidant indices at a dosage of 0.04 g kg(-1). Additionally, ANF exhibited positive effects on energy levels and reduced immobility time in antidepressant behavioral experiments. Moreover, ANF positively influenced the density and infiltration state of renal cells, while mitigating inflammatory enlargement and deformation of liver cells, without inducing any adverse effects in mice. Conclusion: Overall, these findings underscore the significant therapeutic potential of ANF in the treatment of T2DM and its associated complications. By augmenting lipid and glucose metabolism, mitigating oxidative stress and alleviating depression, ANF emerges as a promising candidate for multifaceted intervention. (c) 2023 Society of Chemical Industry. |
| WOS关键词 | ALPHA-GLUCOSIDASE ; MELANIN ; MODEL ; AMYLASE |
| 资助项目 | 14th Five-Year Plan of Qingdao Pilot National Laboratory of Marine Science and Technology[2022QNLM03003-2] ; Shandong Key RD Plan ; Major Scientific and Technological Innovation Project[2022CXGC020413] ; Fujian Science and Technology Planning Project-STS Program[2021 T3013] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:001075206100001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/181703]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Chinese Acad Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 5.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Wen,Xing, Ronge,Yang, Haoyue,et al. Therapeutic potential of enzymatically extracted eumelanin from squid ink in type 2 diabetes mellitus ICR mice: Multifaceted intervention against hyperglycemia, oxidative stress and depression[J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,2023:15. |
| APA | Song, Wen,Xing, Ronge,Yang, Haoyue,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2023).Therapeutic potential of enzymatically extracted eumelanin from squid ink in type 2 diabetes mellitus ICR mice: Multifaceted intervention against hyperglycemia, oxidative stress and depression.JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,15. |
| MLA | Song, Wen,et al."Therapeutic potential of enzymatically extracted eumelanin from squid ink in type 2 diabetes mellitus ICR mice: Multifaceted intervention against hyperglycemia, oxidative stress and depression".JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2023):15. |
入库方式： OAI收割
来源：海洋研究所
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