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Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512

文献类型：期刊论文

作者Chi, Lu-Ping1,2,3; Liu, Dong1,2; Li, Xiao-Ming1,2; Wan, Yupeng1,2; Wang, Bin-Gui1,2,4; Li, Xin1,2,4
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2023-08-31
卷号71期号:36页码:13316-13324
ISSN号0021-8561
关键词marine-derivedfungi pentadepsipeptides p-methoxycinnamoylamide Aspergillus spp. antimicrobial activity
DOI10.1021/acs.jafc.3c02610
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xin(lixin@qdio.ac.cn)
英文摘要Marine fungus-derived natural products are an important source of antimicrobial compounds against marine aquatic pathogens. Here, we describe the isolation and characterization of five new pentadepsipeptides, aspertides A-E (1-5), containing a unique p-methoxycinnamoyl amide group, from the marine fungi Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512. Among them, aspertides B-E (2-5) also possessed uncommon amino acid residues, such as 3-hydroxyproline, 2,3-dihydroxyproline, or pipecolinic acid. The structures of these compounds were elucidated on the basis of NMR and mass spectroscopic analyses. The absolute configurations of them were established by chiral HPLC analyses of the acidic hydrolysates and NMR calculations with DP4+ probability analysis. In bio-activity assays, compounds 4 and 5 exhibited antibacterial activities against aquatic-pathogenic bacteria, including Edwardsiella tarda, Vibrio alginolyticus, Vibrio anguillarum, Vibrio vulnificus, and Staphylococcus aureus, with MIC values of 8-32 mu g/mL.
资助项目This work was financially supported by the National Key Ramp;amp;D Program of China (2022YFC2804700), the National Natural Science Foundation of China (32200022, 42076090, and U2006203), and the Shandong Provincial Natural Science Foundation (ZR2021ZD28).
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001060974700001
源URL[http://ir.qdio.ac.cn/handle/337002/181808]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Li, Xin
作者单位1.Chinese Acad Sci, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,et al. Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(36):13316-13324.
APA Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,Wan, Yupeng,Wang, Bin-Gui,&Li, Xin.(2023).Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(36),13316-13324.
MLA Chi, Lu-Ping,et al."Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.36(2023):13316-13324.

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来源：海洋研究所

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