Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles
文献类型：期刊论文
| 作者 | Chen, Xuelian1; Liu, Lijia2; Shen, Chen1; Liu, Fangyan1; Xu, Enyu1; Chen, Yin1; Jie, Wang1 |
| 刊名 | POLYMERS
 |
| 出版日期 | 2023-05-30 |
| 卷号 | 15期号:11页码:16 |
| 关键词 | layer-by-layer nanoparticle polysaccharide |
| DOI | 10.3390/polym15112510 |
| 通讯作者 | Jie, Wang(011103@zjou.edu.cn) |
| 英文摘要 | In recent years, natural polysaccharides have been widely used in the preparation of drug delivery systems. In this paper, novel polysaccharide-based nanoparticles were prepared by layer-by-layer assembly technology using silica as a template. The layers of nanoparticles were constructed based on the electrostatic interaction between a new pectin named NPGP and chitosan (CS). The targeting ability of nanoparticles was formed by grafting the RGD peptide, a tri-peptide motif containing arginine, glycine, and aspartic acid with high affinity to integrin receptors. The layer-by-layer assembly nanoparticles (RGD-(NPGP/CS)(3)NPGP) exhibited a high encapsulation efficiency (83.23 +/- 6.12%), loading capacity (76.51 +/- 1.24%), and pH-sensitive release property for doxorubicin. The RGD-(NPGP/CS)(3)NPGP nanoparticles showed better targeting to HCT-116 cells, the integrin alpha v beta 3 high expression human colonic epithelial tumor cell line with higher uptake efficiency than MCF7 cells, the human breast carcinoma cell line with normal integrin expression. In vitro antitumor activity tests showed that the doxorubicin-loaded nanoparticles could effectively inhibit the proliferation of the HCT-116 cells. In conclusion, RGD-(NPGP/CS)(3)NPGP nanoparticles have potential as novel anticancer drug carriers because of their good targeting and drug-carrying activity. |
| WOS关键词 | HOLLOW NANOCAPSULES ; RELEASE |
| 资助项目 | National Natural Science Foundation of Zhejiang Province, China[LTGS23D060001] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001003459100001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182293]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Jie, Wang |
| 作者单位 | 1.Zhejiang Ocean Univ, Coll Food & Pharm, Zhoushan 316000, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xuelian,Liu, Lijia,Shen, Chen,et al. Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles[J]. POLYMERS,2023,15(11):16. |
| APA | Chen, Xuelian.,Liu, Lijia.,Shen, Chen.,Liu, Fangyan.,Xu, Enyu.,...&Jie, Wang.(2023).Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles.POLYMERS,15(11),16. |
| MLA | Chen, Xuelian,et al."Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles".POLYMERS 15.11(2023):16. |
入库方式： OAI收割
来源：海洋研究所
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