Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata
文献类型：期刊论文
| 作者 | Wei, Sijie1,2 ; Geng, Lihua1; Yu, Haoyu1,2; Wang, Jing1; Yue, Yang1; Zhang, Quanbin1,2; Wu, Ning1,3,4
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2023-05-25 |
| 卷号 | 28期号:11页码:15 |
| 关键词 | Costaria costata fucoidan idiopathic pulmonary fibrosis |
| DOI | 10.3390/molecules28114343 |
| 通讯作者 | Wu, Ning(wuning@qdio.ac.cn) |
| 英文摘要 | Pulmonary fibrosis is a chronic, progressive, and fatal disease of the interstitial lung. There is currently a lack of efficient therapy to reverse the prognosis of patients. In this study, a fucoidan from Costaria costata was isolated, and its anti-idiopathic fibrosis activity was investigated both in vitro and in vivo. The chemical composition analysis showed that C. costata polysaccharide (CCP) consists of galactose and fucose as the main monosaccharides with a sulfate group content of 18.54%. Further study found that CCP could resist TGF-beta 1-induced epithelial-mesenchymal transition (EMT) in A549 cells by inhibiting the TGF-beta/Smad and PI3K/AKT/mTOR signaling pathways. Moreover, in vivo study found that CCP treatment alleviated bleomycin (BLM)-stimulated fibrosis and inflammation in mice lung tissue. In conclusion, the present study suggests that CCP could protect the lung from fibrosis by relieving the EMT process and inflammation in lung cells. |
| WOS关键词 | TGF-BETA/SMAD ; INDUCED EMT ; MODEL ; ACID |
| 资助项目 | National Key R&D Program of China[2022YFD2401203] ; Nantong Science and Technology project[MS12021037] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001003718200001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182296]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Ning |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Drugs & Bioprod, Qingdao 266237, Peoples R China 4.Nantong Zhongke Marine Sci & Technol Res & Dev Ctr, Nantong 226682, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Sijie,Geng, Lihua,Yu, Haoyu,et al. Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata[J]. MOLECULES,2023,28(11):15. |
| APA | Wei, Sijie.,Geng, Lihua.,Yu, Haoyu.,Wang, Jing.,Yue, Yang.,...&Wu, Ning.(2023).Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata.MOLECULES,28(11),15. |
| MLA | Wei, Sijie,et al."Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata".MOLECULES 28.11(2023):15. |
入库方式： OAI收割
来源：海洋研究所
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