Oyster studies reveal the duplication and functional diversification of Bivalvia caspase-8 genes
文献类型：期刊论文
| 作者 | Deng, Shaoxi1,2 ; Qu, Tao1,4; Zhang, Guofan1,2,3; Xu, Fei1,2,3
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| 刊名 | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2023-06-22 |
| 页码 | 13 |
| ISSN号 | 2096-5508 |
| 关键词 | caspase-8 apoptosis metamorphosis inflammation Crassostrea gigas |
| DOI | 10.1007/s00343-022-2129-7 |
| 通讯作者 | Xu, Fei(xufei@qdio.ac.cn) |
| 英文摘要 | Caspase-8, first classified as a pro-apoptotic caspase, is considered to have arisen from duplication with caspase-10 and involves multiple immune and inflammatory responses in mammals. However, few are known on the phylogeny and function of caspase-8 in molluscs, one of the largest phyla in marine invertebrates. In this study, we conducted phylogenetic and functional analysis on molluscan caspase-8-like genes. Results indicate that duplication occurred in molluscan caspase-8-like genes, resulting in at least two caspase-8 copies in some groups of bivalves. Additional studies in Pacific oyster Crassostrea gigas showed different spatio-temporal expression patterns and subcellular localizations of CgCaspase-8-1 and CgCaspase-8-2. While no interaction was observed between CgCaspase-8-2 and CgFADD, the adaptor molecule in apoptosis, yeast two-hybrid and co-immunoprecipitation assays suggested the interaction between CgCaspase-8-1 and CgFADD, indicating its pro-apoptotic function. In addition, CgCaspase-8-1 showed interaction with the CARD domain of CgRIG-I. Together with two NF-& kappa;B subunits (Cgp105 and CgRel), their transcripts were up-regulated in response to poly(I:C) stimuli, supporting the immune function of both pro, and anti-inflammation. The results provide insight into the evolution and functional diversification of Bivalvia caspase-8 genes. |
| WOS关键词 | NF-KAPPA-B ; TNF RECEPTOR ; CELL-DEATH ; APOPTOSIS ; ACTIVATION ; PATHWAY ; CLONING ; DOMAIN ; RECOGNITION ; ILLUSTRATOR |
| WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:001011988000001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182358]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Fei |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266000, Peoples R China 4.Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Shaoxi,Qu, Tao,Zhang, Guofan,et al. Oyster studies reveal the duplication and functional diversification of Bivalvia caspase-8 genes[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2023:13. |
| APA | Deng, Shaoxi,Qu, Tao,Zhang, Guofan,&Xu, Fei.(2023).Oyster studies reveal the duplication and functional diversification of Bivalvia caspase-8 genes.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,13. |
| MLA | Deng, Shaoxi,et al."Oyster studies reveal the duplication and functional diversification of Bivalvia caspase-8 genes".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2023):13. |
入库方式： OAI收割
来源：海洋研究所
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