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Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health

文献类型：期刊论文

作者Ding, Kui1,2,3; Zhuo, Pengji3,4; Ge, Meiling1,2; Liao, Xiaomei1,2; Mo, Jing1,2; Liu, Shilin3; Xu, Qinzeng1,2; Zhang, Xuelei1,2
刊名FRONTIERS IN MARINE SCIENCE
出版日期2023-09-28
卷号10页码:15
关键词sea cucumber BDE-47 body wall metabolite metabolic pathway
DOI10.3389/fmars.2023.1205538
通讯作者Xu, Qinzeng(xuqinzeng@fio.org.cn) ; Zhang, Xuelei(zhangxl@fio.org.cn)
英文摘要Introduction: Sea cucumbers are cultivated mainly for their valuable body wall. Polybrominated diphenyl ethers are common persistent pollutants in sea waters with known impacts on aquatic animals nonetheless not yet studied for the body wall of sea cucumbers. Methods: Using ltra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS), we investigated the metabolic impact of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the body wall of Apostichopus japonicus. etabolite changes and metabolic pathway alterations were assessed in response to three distinct concentrations of BDE-47: 0.1 mu g/L, 1.0 mu g/L, and 10.0 mu g/L. REsults: Exposure to BDE-47 led to notable alterations in the metabolic profiles of the body wall. A total of 95 similar to 102 metabolites in the 0.1 similar to 10.0 mu g/L BDE-47 treated group were altered significantly, and various disrupted metabolic pathways were identified and characterized. These metabolites and metabolic pathways were mainly involved in lipid metabolism, energy metabolism, immunity, oxidative stress, inflammation, and neurotoxicity. Discussion: The findings of our study shed light on the potential health risks that polybrominated diphenyl ethers present to sea cucumbers. This underscores the imperative for both researchers and policymakers to delve deeper into further investigations and studies. These results indicate the necessity for enhanced monitoring and management practices within the sea cucumber aquaculture industry to mitigate the impact of these persistent organic pollutants and protect the health and safety of this valuable resource.
WOS关键词POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; 2,2',4,4'-TETRABROMODIPHENYL ETHER ; GREEN TEA ; OXIDATIVE STRESS ; BIOTRANSFORMATION ; IDENTIFICATION ; ACCUMULATION ; MECHANISMS ; RESPONSES
资助项目This research was funded by the National Natural Science Foundation of China (Grant No. 42106131).[42106131] ; National Natural Science Foundation of China
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:001083319800001
源URL[http://ir.qdio.ac.cn/handle/337002/181628]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Xu, Qinzeng; Zhang, Xuelei
作者单位1.Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao, Peoples R China
2.Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
4.North China Sea Bur Minist Nat Resources, Marine & Isl Management Dept, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Kui,Zhuo, Pengji,Ge, Meiling,et al. Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health[J]. FRONTIERS IN MARINE SCIENCE,2023,10:15.
APA Ding, Kui.,Zhuo, Pengji.,Ge, Meiling.,Liao, Xiaomei.,Mo, Jing.,...&Zhang, Xuelei.(2023).Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health.FRONTIERS IN MARINE SCIENCE,10,15.
MLA Ding, Kui,et al."Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health".FRONTIERS IN MARINE SCIENCE 10(2023):15.

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来源：海洋研究所

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