Vitamin B2-Based Ferroptosis Promoter for Sono-Enhanced Nanocatalytic Therapy of Triple-Negative Breast Cancer
文献类型：期刊论文
| 作者 | Zhou, Mengjiao5; Yuan, Minjian5; Jin, Yilan5; Zhou, Qianqian5; Yu, Yuting5; Li, Jianan5; Dai, Xing3,4; Zheng, Xiaohua5; Yu, Haijun1,2 ; Wang, Weiqi5
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2023-09-15 |
| 页码 | 12 |
| ISSN号 | 1616-301X |
| 关键词 | ferroptosis nanocatalytic therapy oxidative stress redox homeostasis |
| DOI | 10.1002/adfm.202303899 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) ; Wang, Weiqi(wwq1990@ntu.edu.cn) |
| 英文摘要 | Ferroptosis featured by iron-dependent lipid peroxidation plays a critical role in tumor regression, offering an alternative therapeutic target for the treatment of aggressive triple-negative breast cancer. However, the traditional delivery strategy to enrich iron deposition is limited in producing a surplus of lipid oxidation because of the aggressive antioxidant response established in solid tumors. Here, vitamin B2-ferric chloride nanocomplex self-assembled through the coordination of ferric iron and hydroxy groups to simultaneously promote iron accumulation and oxidative stress is employed. It is observed that the self-assembly nanostructures with appropriate size enable effective delivery of the therapeutic agents to the tumor site and cancer cells. More importantly, sonosensitizer vitamin B2 and ferric chloride cooperatively facilitate the production of reactive oxygen species and amplify nanocatalytic therapy. To further disrupt the antioxidant system, metformin with solute carrier family 7 member 11 inhibitory activity is used to synergistically boost ferroptosis of tumor cells. The combinational ferroptosis promoter exhibits augmented nanocatalytic antitumor efficacy in 4T1 tumor-bearing mice with negligible adverse effects. Taken together, this study may provide a novel paradigm of self-assembled vitamin B2-ferric nanocomplex for ferroptosis regulation. Vitamin B2-based ferroptosis promoter is developed for sono-amplified nanocatalytic cancer therapy. The nanoplatform constructed by coordination-driven self-assembly demonstrates superior acoustic properties, enabling simultaneous regulation of iron accumulation, redox homeostasis, and oxidative stress. This biocompatible nanoplatform enhances tumor elimination via synergistic sonodynamic and ferroptotic therapy, providing an instructive strategy for the clinical treatment of breast carcinoma.image |
| WOS关键词 | EMERGING MECHANISMS ; STRATEGY |
| 资助项目 | National Natural Science Foundation of China[KFJN2271] ; Natural Science Foundation of Jiangsu Province ; Large Instruments Open Foundation of Nantong University ; Shanghai Institute of Materia Medica, CAS ; [31900990] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:001065561200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307158]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yu, Haijun; Wang, Weiqi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Soochow Univ, Sch Radiol & Interdisciplinary Sci, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China 4.Soochow Univ, Sch Radiat Med & Protect, State Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China 5.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Mengjiao,Yuan, Minjian,Jin, Yilan,et al. Vitamin B2-Based Ferroptosis Promoter for Sono-Enhanced Nanocatalytic Therapy of Triple-Negative Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2023:12. |
| APA | Zhou, Mengjiao.,Yuan, Minjian.,Jin, Yilan.,Zhou, Qianqian.,Yu, Yuting.,...&Wang, Weiqi.(2023).Vitamin B2-Based Ferroptosis Promoter for Sono-Enhanced Nanocatalytic Therapy of Triple-Negative Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,12. |
| MLA | Zhou, Mengjiao,et al."Vitamin B2-Based Ferroptosis Promoter for Sono-Enhanced Nanocatalytic Therapy of Triple-Negative Breast Cancer".ADVANCED FUNCTIONAL MATERIALS (2023):12. |
入库方式： OAI收割
来源：上海药物研究所
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