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Astrocyte metabolism and signaling pathways in the CNS

文献类型：期刊论文

作者Zhang, Yong-mei2,3,4; Qi, Ying-bei2,3,4; Gao, Ya-nan1,3; Chen, Wen-gang1,3; Zhou, Ting2,3; Zang, Yi2,3; Li, Jia1,2,3,4
刊名FRONTIERS IN NEUROSCIENCE
出版日期2023-09-04
卷号17页码:18
关键词astrocyte metabolism neurological disorders energy imbalance neural circuit
DOI10.3389/fnins.2023.1217451
通讯作者Zang, Yi(yzang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn)
英文摘要Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression, Alzheimer's disease, and epilepsy. Although the metabolic functionalities of astrocytes are well known, their relationship to neurological disorders is poorly understood. The ways in which astrocytes regulate the metabolism of glucose, amino acids, and lipids have all been implicated in neurological diseases. Metabolism in astrocytes has also exhibited a significant influence on neuron functionality and the brain's neuro-network. In this review, we focused on metabolic processes present in astrocytes, most notably the glucose metabolic pathway, the fatty acid metabolic pathway, and the amino-acid metabolic pathway. For glucose metabolism, we focused on the glycolysis pathway, pentose-phosphate pathway, and oxidative phosphorylation pathway. In fatty acid metabolism, we followed fatty acid oxidation, ketone body metabolism, and sphingolipid metabolism. For amino acid metabolism, we summarized neurotransmitter metabolism and the serine and kynurenine metabolic pathways. This review will provide an overview of functional changes in astrocyte metabolism and provide an overall perspective of current treatment and therapy for neurological disorders.
WOS关键词MAJOR DEPRESSIVE DISORDER ; PENTOSE-PHOSPHATE PATHWAY ; GLUTAMATE-GLUTAMINE CYCLE ; BRAIN GLUCOSE-METABOLISM ; A-BETA CLEARANCE ; ALZHEIMERS-DISEASE ; D-SERINE ; IN-VIVO ; EXOGENOUS GLUTAMATE ; GLYCOLYTIC-ENZYMES
资助项目National Natural Science Foundation of China[81971265]
WOS研究方向Neurosciences & Neurology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:001066907600001
源URL[http://119.78.100.183/handle/2S10ELR8/307170]  
专题新药研究国家重点实验室
通讯作者Zang, Yi; Li, Jia
作者单位1.China Pharmaceut Univ, Inst Pharmaceut Sci, Nanjing, Jiangsu, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yong-mei,Qi, Ying-bei,Gao, Ya-nan,et al. Astrocyte metabolism and signaling pathways in the CNS[J]. FRONTIERS IN NEUROSCIENCE,2023,17:18.
APA Zhang, Yong-mei.,Qi, Ying-bei.,Gao, Ya-nan.,Chen, Wen-gang.,Zhou, Ting.,...&Li, Jia.(2023).Astrocyte metabolism and signaling pathways in the CNS.FRONTIERS IN NEUROSCIENCE,17,18.
MLA Zhang, Yong-mei,et al."Astrocyte metabolism and signaling pathways in the CNS".FRONTIERS IN NEUROSCIENCE 17(2023):18.

入库方式： OAI收割

来源：上海药物研究所

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