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A zinc-modified Anemarrhena asphodeloides polysaccharide complex enhances immune activity via the NF-?B and MAPK signaling pathways

文献类型：期刊论文

作者Zhang, Shaojie6; Zhang, Qian4; Li, Chong3; Xing, Na2; Zhou, Pengfei1; Jiao, Yukun5
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2023-09-30
卷号249页码:12
ISSN号0141-8130
关键词Anemarrhena asphodeloides Bunge Zinc modification Immunoregulatory activity Zebrafish NF-kappa B signaling pathway MAPKs signaling pathway
DOI10.1016/j.ijbiomac.2023.126017
通讯作者Zhang, Shaojie(ZhangSJ_Polymers@163.com) ; Jiao, Yukun(jiaoyukun@simm.ac.cn)
英文摘要Anemarrhena asphodeloides polysaccharide (AAP70-1) was reported to have immunomodulatory effects in our previous report. To further improve the immunomodulatory effects of AAP70-1, an A. asphodeloides polysaccharide-zinc complex (AAP-Zn) was synthesized using a ZnCl2 modification method, and the potential mechanisms by which AAP-Zn activates macrophages were investigated. The results showed that the structural features of AAP-Zn were similar to those of AAP70-1 with a Zn content of 0.2 %, confirming that Zn mainly interacted with AAP70-1 by forming Zn-O coordination bonds and Zn.OH bonds. In addition, the administration of AAP70-1 and AAP-Zn effectively improved the immunomodulatory effects by enhancing phagocytosis and upregulating the mRNA expression of cytokines (TNF-alpha, IL-6, IL-1 beta, and IL-18), as well as increasing the production levels of nitric oxide (NO) and reactive oxygen species (ROS) in zebrafish embryos. The intracellular mechanism by which AAP-Zn activates macrophages was found to involve activation of the NF-kappa B and MAPK signaling pathways. Our findings suggested that AAP-Zn may be a potential immunopotentiator in the field of biomedicine or functional foods.
WOS关键词ANTIPROLIFERATIVE ACTIVITY ; HEALTH ; INNATE ; AGENTS
资助项目Medical Scientific Research Foundation of Guangdong Province[B2023411] ; Guangdong Medical University Research Foundation[4SG23198G] ; Discipline construction project of Guangdong Medical University[4SG23282G] ; Guangzhou Basic and Applied Basic Research Foundation[2023A04J1154] ; College Students' Innovation and Entrepreneurship Training Program ; [S202110573035]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
出版者ELSEVIER
WOS记录号WOS:001066114800001
源URL[http://119.78.100.183/handle/2S10ELR8/307266]  
专题新药研究国家重点实验室
通讯作者Zhang, Shaojie; Jiao, Yukun
作者单位1.Guangdong Med Univ, Sch Basic Med Sci, Dongguan 523808, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Joint Sch Life Sci, CAS Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
4.Guangdong Pharmaceut Univ, Guangdong Prov Engn Ctr Top Precise Drug Delivery, Sch Pharm, Guangdong Prov Key Lab Adv Drug Delivery, Guangzhou 510006, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.Guangdong Med Univ, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Shaojie,Zhang, Qian,Li, Chong,et al. A zinc-modified Anemarrhena asphodeloides polysaccharide complex enhances immune activity via the NF-?B and MAPK signaling pathways[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,249:12.
APA Zhang, Shaojie,Zhang, Qian,Li, Chong,Xing, Na,Zhou, Pengfei,&Jiao, Yukun.(2023).A zinc-modified Anemarrhena asphodeloides polysaccharide complex enhances immune activity via the NF-?B and MAPK signaling pathways.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,249,12.
MLA Zhang, Shaojie,et al."A zinc-modified Anemarrhena asphodeloides polysaccharide complex enhances immune activity via the NF-?B and MAPK signaling pathways".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 249(2023):12.

入库方式： OAI收割

来源：上海药物研究所

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