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Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism

文献类型：期刊论文

作者Wang, Jue; Guo, Xiaozhen8; Zou, Ziyuan7,8; Yu, Minjun5,8; Li, Xueling9; Xu, Hualing6,8; Chen, Yiping9; Jiao, Tingying4,8; Wang, Kanglong8; Ma, Yuandi5,8
刊名BIOMEDICINE & PHARMACOTHERAPY
出版日期2023-10-01
卷号166页码:15
ISSN号0753-3322
关键词Ootheca mantidis Unilateral ureteral obstruction Renal interstitial fibrosis Apoptosis Akkermansia muciniphila Glutamine
DOI10.1016/j.biopha.2023.115434
通讯作者Xie, Cen(xiecen@simm.ac.cn) ; Zhong, Yifei(yifeilily@126.com)
英文摘要Renal interstitial fibrosis (RIF), a progressive process affecting the kidneys in chronic kidney disease (CKD), currently lacks an effective therapeutic intervention. Traditional Chinese medicine (TCM) has shown promise in reducing RIF and slowing CKD progression. In this study, we demonstrated the dose-dependent attenuation of RIF by Ootheca mantidis (SPX), a commonly prescribed TCM for CKD, in a mouse model of unilateral ureteral obstruction (UUO). RNA-sequencing analysis suggested that SPX treatment prominently downregulated apoptosis and inflammation-associated pathways, thereby inhibiting the fibrogenic signaling in the kidney. We further found that transplantation of fecal microbiota from SPX-treated mice conferred protection against renal injury and fibrosis through suppressing apoptosis in UUO mice, indicating that SPX ameliorated RIF via remodeling the gut microbiota and reducing apoptosis in the kidneys. Further functional exploration of the gut microbiota combined with fecal metabolomics revealed increased levels of some probiotics, including Akkermansia muciniphila (A. muciniphila), and modulations in glutamine-related amino acid metabolism in UUO mice treated with SPX. Subsequent colonization of A. muciniphila and supplementation with glutamine effectively mitigated cell apoptosis and RIF in UUO mice. Collectively, these findings unveil a functionally A. muciniphilaand glutamine-involved gut-renal axis that contributes to the action of SPX, and provide important clue for the therapeutic potential of SPX, A. muciniphila, and glutamine in combatting RIF.
WOS关键词CHRONIC KIDNEY-DISEASE ; P-CRESYL SULFATE ; INTERSTITIAL FIBROSIS ; INDOXYL SULFATE ; RAT MODEL ; ACTIVATION ; MECHANISMS ; INSIGHTS ; DAMAGE ; AXIS
资助项目National Key Research and Devel- opment Program of China[2021YFA1301200] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB39020600] ; National Natural Science Foundation of China[2019-81973772] ; National Natural Science Foundation of China[82222071] ; National Natural Science Foundation of China[82104253] ; National Natural Science Foundation of China[81973456] ; Shanghai Municipality Science and Technology Commission[20QA1411200] ; Shanghai Hospital Development center[SHDC2022CRD003]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号WOS:001075540100001
源URL[http://119.78.100.183/handle/2S10ELR8/307269]  
专题新药研究国家重点实验室
通讯作者Xie, Cen; Zhong, Yifei
作者单位1.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Div Nephrol, 725 South Wanping Rd, Shanghai 200032, Peoples R China
2.East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China
3.East China Normal Univ, Inst Biomed Sci, Shanghai 200241, Peoples R China
4.Fudan Univ, Human Phenome Inst, Sch Life Sci, Shanghai, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China
7.Shanghai Jiao Tong Univ, Ctr Fatty Liver, Dept Gastroenterol, Xinhua Hosp,Sch Med, Shanghai, Peoples R China
8.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China
9.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Div Nephrol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jue,Guo, Xiaozhen,Zou, Ziyuan,et al. Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,166:15.
APA Wang, Jue.,Guo, Xiaozhen.,Zou, Ziyuan.,Yu, Minjun.,Li, Xueling.,...&Zhong, Yifei.(2023).Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism.BIOMEDICINE & PHARMACOTHERAPY,166,15.
MLA Wang, Jue,et al."Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism".BIOMEDICINE & PHARMACOTHERAPY 166(2023):15.

入库方式： OAI收割

来源：上海药物研究所

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