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Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect

文献类型：期刊论文

作者Hou, Jiazhen6,7; Xiong, Wei4,5; Shao, Xinyue6; Long, Li4,6; Chang, Ya6; Chen, Guihua4,6; Wang, Li2,3; Wang, Zhicheng3; Huang, Yongzhuo1,5,6,7
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2023-09-20
页码10
关键词platelet storage lesion platelet storage liposome resveratrol antioxidant
ISSN号1944-8244
DOI10.1021/acsami.3c09935
通讯作者Wang, Zhicheng(ahwzc@126.com) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Platelet transfusion is essential in the treatment of platelet-related diseases and the prevention of bleeding in patients with surgical procedures. Platelet transfusion efficacy and shelf life are limited mainly by the development of platelet storage lesion (PSL). Mitigating PSL is the key to prolonging the platelet shelf life and reducing wastage. Excess intracellular reactive oxygen species (ROS) are one of the main factors causing PSL. In this study, we explored a nanomedicine strategy to improve the quality and functions of platelets in storage. Resveratrol (Res), a natural plant product, is known for its antioxidative effect. However, medical applications of Res are limited due to its low water solubility and stability. Therefore, we used a resveratrol-loaded liposomal system (Res-Lipo) to better utilize the antioxidant effect of the drug. This study aimed to evaluate the effect of Res-Lipo on platelet oxidative stress and alleviation of PSL during the storage time. Res-Lipo scavenged intracellular ROS and inhibited platelet apoptosis and activation during storage. Res-Lipo not only maintained mitochondrial function but also improved platelet aggregation in response to adenosine 5'-diphosphate. These results revealed that Res-Lipo ameliorated PSL and prolonged the platelet survival time in vivo. The strategy provides a potential method for extending the platelet storage time and might be considered a potential and safe additive to alleviate PSL.
WOS关键词BIOAVAILABILITY ; ACTIVATION ; GENERATION ; CLEARANCE ; AGITATION ; ADHESION ; COLLAGEN ; SYSTEMS ; PROTEIN
资助项目National Key Research and Development Program of China (China)[2021YFC2400600] ; National Key Research and Development Program of China (China)[2021YFE0103100] ; NFSC (China)[81925035] ; National Foreign Expert Program[82050410361] ; Chinese Pharmaceutical Association-Yiling Joint Project[CPAYLJ201901] ; HighLevel New RD Institute[2019B090904008] ; High-Level Innovative Research Institute from the Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001070022200001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/307278]  
专题新药研究国家重点实验室
通讯作者Wang, Zhicheng; Huang, Yongzhuo
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Shanghai 201203, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Ctr Clin Mol Med Detect, Chongqing 400016, Peoples R China
3.Fudan Univ, Huashan Hosp, Shanghai Med Coll, Dept Transfus Med, Shanghai 200040, Peoples R China
4.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510450, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
7.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Hou, Jiazhen,Xiong, Wei,Shao, Xinyue,et al. Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect[J]. ACS APPLIED MATERIALS & INTERFACES,2023:10.
APA Hou, Jiazhen.,Xiong, Wei.,Shao, Xinyue.,Long, Li.,Chang, Ya.,...&Huang, Yongzhuo.(2023).Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect.ACS APPLIED MATERIALS & INTERFACES,10.
MLA Hou, Jiazhen,et al."Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect".ACS APPLIED MATERIALS & INTERFACES (2023):10.

入库方式： OAI收割

来源：上海药物研究所

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