Densely Functionalized Macrocyclic Sesquiterpene Pyridine Alkaloids from Maytenus austroyunnanensis
文献类型：期刊论文
| 作者 | Ji, Kai-Long3; Fan, Yao-Yue3; Gong, Qi3; Liu, Qun-Fang3 ; Cui, Ming-Jun2; Fu, Kai-Cong2; Zhang, Hai-Yan3; Yue, Jian-Min1,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2023-09-20 |
| 页码 | 11 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00504 |
| 通讯作者 | Zhang, Hai-Yan(hyzhang@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Eleven densely functionalized new dihydro-beta-agarofuran sesquiterpenoid derivatives, named maytenoids A-K (1-11), as well as one known analog, were isolated and characterized from Maytenus austroyunnanensis. Their structures were assigned based on analysis of spectroscopic data and X-ray crystallography. Compounds 1-9 are macrocyclic sesquiterpene pyridine alkaloids generated by the respective acylation of the hydroxy groups at C-3 and C-13 of dihydro-beta-agarofuran sesquiterpenoids via diverse pyridine dicarboxylic acids. Compounds 1, 2, 5-10, and 12 exhibited significant inhibitory effects on NO production at 10 mu M in lipopolysaccharide (LPS)-stimulated BV2 cells. |
| WOS关键词 | BETA-AGAROFURAN SESQUITERPENES ; ABC-RING SYSTEM ; TRIPTERYGIUM-WILFORDII ; ROOTS ; MAYTOLINE ; AGENTS |
| 资助项目 | National Natural Science Foundation[22237007] ; Biological Resources Program of Chinese Academy of Sciences[KFJ-BRP-008-001] ; CAMS Innovation Fund for Medical Sciences of the P. R. China[2019-I2M-5080] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001069969900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307281]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Hai-Yan; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China 2.Puer Natl Inst Ethn Tradit Med, Puer 665000, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Kai-Long,Fan, Yao-Yue,Gong, Qi,et al. Densely Functionalized Macrocyclic Sesquiterpene Pyridine Alkaloids from Maytenus austroyunnanensis[J]. JOURNAL OF NATURAL PRODUCTS,2023:11. |
| APA | Ji, Kai-Long.,Fan, Yao-Yue.,Gong, Qi.,Liu, Qun-Fang.,Cui, Ming-Jun.,...&Yue, Jian-Min.(2023).Densely Functionalized Macrocyclic Sesquiterpene Pyridine Alkaloids from Maytenus austroyunnanensis.JOURNAL OF NATURAL PRODUCTS,11. |
| MLA | Ji, Kai-Long,et al."Densely Functionalized Macrocyclic Sesquiterpene Pyridine Alkaloids from Maytenus austroyunnanensis".JOURNAL OF NATURAL PRODUCTS (2023):11. |
入库方式： OAI收割
来源：上海药物研究所
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