Dual stimuli-activatable versatile nanoplatform for photodynamic therapy and chemotherapy of triple-negative breast cancer
文献类型：期刊论文
| 作者 | Xu, Jie4; Lai, Yi2,3; Wang, Fengyang4; Zou, Zhifeng4; Pei, Renjun1; Yu, Haijun2,3 ; Xu, Zhiai4
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| 刊名 | CHINESE CHEMICAL LETTERS
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| 出版日期 | 2023-12-01 |
| 卷号 | 34期号:12页码:9 |
| 关键词 | Cancer theranostics Precise therapy Combinatorial therapy Photodynamic therapy Triple-negative breast cancer |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2023.108332 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) ; Xu, Zhiai(zaxu@chem.ecnu.edu.cn) |
| 英文摘要 | Photodynamic therapy (PDT) has emerged as an efficient cancer treatment method with minimal invasiveness. However, the majority of current photosensitizers (PSs) display severe dark toxicity and low tumor specificity due to their "always-on" photoactivity in blood circulation. To address this concern, we herein report a series of acid-activatable PSs for ultrasensitive PDT of triple-negative breast tumors. These set of novel PSs are synthesized by covalently modifying tetrakis(4-carboxyphenyl)porphyrin (TCPP) with a variety of tertiary amines for acidity-activatable fluorescence imaging and reactive oxygen species (ROS) generation. The resultant TCPP derivatives are grafted with a poly(ethylene glycol) (PEG) chain via a matrix metalloproteinase-2 (MMP-2)-liable peptide spacer and chelated with Mn 2 + for magnetic resonance imaging (MRI) capability. The PEGylated TCPP derivatives are amphiphilic and self-assemble into micellar nanoparticles to elongate blood circulation and for tumor-specific PDT. We further demonstrate that the PEGylated TCPP nanoparticles could serve as a nanoplatform to deliver the anticancer drug doxorubicin (DOX) and perform fluorescence image-guided combinatorial PDT and chemotherapy, which efficiently suppress the growth of 4T1 breast tumors and lung metastases in a mouse model. These acid-activatable PS-incorporated nanoparticles might provide a versatile platform for precise PDT and combinatorial breast cancer therapy.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| WOS关键词 | TUMOR ; PH ; NANOPARTICLES ; CELLS ; PENETRATION ; CONJUGATION ; MICELLES ; STRATEGY ; EFFICACY |
| 资助项目 | National Natural Science Foundation of China[82102915] ; National Natural Science Foundation of China[22074043] ; National Natural Science Foundation of China[U22A20328] ; China Postdoctoral Science Foundation[2021424] ; Shanghai Post-Doctoral Excellence Program[LG-QS-202206-04] ; Lingang Laboratory ; [2021M700157] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001078342100001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307306]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Xu, Zhiai |
| 作者单位 | 1.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Key Lab Nanobio Interface, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jie,Lai, Yi,Wang, Fengyang,et al. Dual stimuli-activatable versatile nanoplatform for photodynamic therapy and chemotherapy of triple-negative breast cancer[J]. CHINESE CHEMICAL LETTERS,2023,34(12):9. |
| APA | Xu, Jie.,Lai, Yi.,Wang, Fengyang.,Zou, Zhifeng.,Pei, Renjun.,...&Xu, Zhiai.(2023).Dual stimuli-activatable versatile nanoplatform for photodynamic therapy and chemotherapy of triple-negative breast cancer.CHINESE CHEMICAL LETTERS,34(12),9. |
| MLA | Xu, Jie,et al."Dual stimuli-activatable versatile nanoplatform for photodynamic therapy and chemotherapy of triple-negative breast cancer".CHINESE CHEMICAL LETTERS 34.12(2023):9. |
入库方式： OAI收割
来源：上海药物研究所
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