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Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation

文献类型：期刊论文

作者Yu, Dan-Dan4; Ke, Lin-Mao4; Liu, Jiao3; Li, Song-Wei2; Su, Ming-Zhi1; Yao, Li-Gong1,3; Luo, Hui4; Guo, Yue-Wei1,2,3
刊名MOLECULES
出版日期2023-10-01
卷号28期号:19页码:10
关键词marine natural product Sinularia nanolobata structure elucidation cytotoxicity
DOI10.3390/molecules28196892
通讯作者Luo, Hui(luohui@gdmu.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Three new cembranoids (1-3) and a new casbanoid (4), along with three known analogues (5-7), have been isolated from the soft coral Sinularia nanolobata collected off Ximao Island. The structures, including the absolute configurations of new compounds, were established using extensive spectroscopic data analysis, time-dependent density functional theory/electronic circular dichroism (TDDFT-ECD) calculations, and the comparison with spectroscopic data of known compounds. In the in vitro bioassay, compounds 1 and 5 exhibited moderate cytotoxic activities against human erythroleukemia (HEL) cell lines, with IC50 values of 37.1 and 42.4 mu M, respectively.
WOS关键词TERPENOIDS ; CONSTITUENTS ; SARCOPHYTON
资助项目The authors would like to thank X.-B. Li from Hainan University for the taxonomic identification of the soft coral material.
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001084882300001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/307400]  
专题新药研究国家重点实验室
通讯作者Luo, Hui; Guo, Yue-Wei
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
2.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Guangdong Med Univ, Coll Pharm, Zhanjiang 524023, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Dan-Dan,Ke, Lin-Mao,Liu, Jiao,et al. Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation[J]. MOLECULES,2023,28(19):10.
APA Yu, Dan-Dan.,Ke, Lin-Mao.,Liu, Jiao.,Li, Song-Wei.,Su, Ming-Zhi.,...&Guo, Yue-Wei.(2023).Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation.MOLECULES,28(19),10.
MLA Yu, Dan-Dan,et al."Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation".MOLECULES 28.19(2023):10.

入库方式： OAI收割

来源：上海药物研究所

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