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Deubiquitylating Enzymes in Cancer and Immunity

文献类型：期刊论文

作者Ren, Jiang9; Yu, Peng8; Liu, Sijia6,7; Li, Ran9; Niu, Xin4,5; Chen, Yan9; Zhang, Zhenyu3; Zhou, Fangfang2; Zhang, Long1,4,5,7,9
刊名ADVANCED SCIENCE
出版日期2023-10-27
页码37
关键词cancer deubiquitylating enzymes (DUBs) immunity therapeutic approach
DOI10.1002/advs.202303807
通讯作者Zhang, Zhenyu(fcczhangzy1@zzu.edu.cn) ; Zhou, Fangfang(zhoufangfang@suda.edu.cn) ; Zhang, Long(l_zhang@zju.edu.cn)
英文摘要Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome by removing the post-translational modification ubiquitin moiety from substrates. Numerous DUBs have been demonstrated specificity for cleaving a certain type of ubiquitin linkage or positions within ubiquitin chains. Moreover, several DUBs perform functions through specific protein-protein interactions in a catalytically independent manner, which further expands the versatility and complexity of DUBs' functions. Dysregulation of DUBs disrupts the dynamic equilibrium of ubiquitome and causes various diseases, especially cancer and immune disorders. This review summarizes the Janus-faced roles of DUBs in cancer including proteasomal degradation, DNA repair, apoptosis, and tumor metastasis, as well as in immunity involving innate immune receptor signaling and inflammatory and autoimmune disorders. The prospects and challenges for the clinical development of DUB inhibitors are further discussed. The review provides a comprehensive understanding of the multi-faced roles of DUBs in cancer and immunity. This review presents the fundamental understanding of deubiquitinating enzymes (DUBs) and then outlines the mechanisms and multi-role of DUBs in determining the occurrence and development of tumor and immune disorders. DUBs in the crosstalk between cancer and immune response is then presented. The therapeutic potential and clinical translation of DUB inhibitors are also summarized.image
WOS关键词NF-KAPPA-B ; PAPAIN-LIKE PROTEASE ; SMALL-MOLECULE INHIBITOR ; TUMOR-SUPPRESSOR CYLD ; DNA-DAMAGE RESPONSE ; E3 UBIQUITIN LIGASE ; PREVENTS CHROMOSOME INSTABILITY ; PROMOTES CELL-PROLIFERATION ; CHIP-MEDIATED DEGRADATION ; I INTERFERON INDUCTION
资助项目The current work was supported by a special program from the Ministry of Science and Technology of China (2021YFA1101000, 2022YFA1105200), the Chinese National Natural Science Funds (U20A20393, U20A201376, 32125016, 31701234, 91753139, 31925013, 31671457,[2021YFA1101000] ; The current work was supported by a special program from the Ministry of Science and Technology of China (2021YFA1101000, 2022YFA1105200), the Chinese National Natural Science Funds (U20A20393, U20A201376, 32125016, 31701234, 91753139, 31925013, 31671457,[2022YFA1105200] ; Ministry of Science and Technology of China[U20A20393] ; Ministry of Science and Technology of China[U20A201376] ; Ministry of Science and Technology of China[32125016] ; Ministry of Science and Technology of China[31701234] ; Ministry of Science and Technology of China[91753139] ; Ministry of Science and Technology of China[31925013] ; Ministry of Science and Technology of China[31671457] ; Ministry of Science and Technology of China[31870902] ; Ministry of Science and Technology of China[32070907] ; Ministry of Science and Technology of China[32100699] ; Ministry of Science and Technology of China[32200575] ; Ministry of Science and Technology of China[82273493] ; Ministry of Science and Technology of China[31871405] ; Ministry of Science and Technology of China[81760041] ; Chinese National Natural Science Funds[LD19C070001] ; Zhejiang Natural Science Fund[19KJA550003] ; Jiangsu National Science Foundation[JCYJ20220530144207017] ; Fundamental research program of The Shenzhen Science and Technology Innovation Commission
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001090683900001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/307539]  
专题中国科学院上海药物研究所
通讯作者Zhang, Zhenyu; Zhou, Fangfang; Zhang, Long
作者单位1.Zhejiang Univ, Canc Ctr, Hangzhou 310058, Zhejiang, Peoples R China
2.Soochow Univ, Inst Biol & Med Sci, Suzhou 215123, Peoples R China
3.Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450003, Henan, Peoples R China
4.Zhejiang Univ, Life Sci Inst, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Peoples R China
5.Zhejiang Univ, Life Sci Inst, MOE Lab Biosyst Homeostasis & Protect, Hangzhou 310058, Peoples R China
6.Key Lab Precis Diag & Treatment Hepatobiliary & Pa, Hangzhou 310058, Peoples R China
7.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Int Biomed X Res Ctr, R China, Hangzhou, Peoples R China
8.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Guangdong, Peoples R China
9.Sun Yat sen Univ, Affiliated Hosp 8, Shenzhen 518033, Peoples R China
推荐引用方式
GB/T 7714		 Ren, Jiang,Yu, Peng,Liu, Sijia,et al. Deubiquitylating Enzymes in Cancer and Immunity[J]. ADVANCED SCIENCE,2023:37.
APA Ren, Jiang.,Yu, Peng.,Liu, Sijia.,Li, Ran.,Niu, Xin.,...&Zhang, Long.(2023).Deubiquitylating Enzymes in Cancer and Immunity.ADVANCED SCIENCE,37.
MLA Ren, Jiang,et al."Deubiquitylating Enzymes in Cancer and Immunity".ADVANCED SCIENCE (2023):37.

入库方式： OAI收割

来源：上海药物研究所

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