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Nobachelins, new siderophores from Nocardiopsis baichengensis protecting Caenorhabditis elegans from Pseudomonas aeruginosa infection

文献类型：期刊论文

作者Zhao, Haowen3,4,5; Ren, Yuhao2,5; Xie, Feng5; Dai, Huanqin1; Liu, Hongwei1; Fu, Chengzhang4,5; Mueller, Rolf4,5
刊名SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
出版日期2023-12-01
卷号8期号:4页码:640-646
关键词Nocardiopsis Genome mining Siderophore Pseudomonas aeruginosa Infection
ISSN号2405-805X
DOI10.1016/j.synbio.2023.09.007
通讯作者Mueller, Rolf()
英文摘要The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense. In this paper, we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses, leading to the discovery of a new group of catecholate-hydroxamate siderophores, nobachelins, from Nocardiopsis baichengensis DSM 44845. Nobachelin biosynthesis genes are conserved in several bacteria from the family Nocardiopsidaceae. Structurally, nobachelins feature fatty-acylated hydroxyornithine and a rare chlorinated catecholate group. Intriguingly, nobachelins rescued Caenorhabditis elegans from Pseudomonas aeruginosa-mediated killing.
WOS关键词IRON ACQUISITION ; L-ORNITHINE ; BIOSYNTHESIS ; AMYCHELIN ; PROTEIN ; SP.
资助项目Helmholtz International Lab[InterLabs0007] ; Helmholtz Association, Germany[ZD202125] ; Helmholtz Association, Germany ; Office of China Postdoc Council (OCPC) , China
WOS研究方向Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:001090246200001
出版者KEAI PUBLISHING LTD
源URL[http://119.78.100.183/handle/2S10ELR8/307548]  
专题新药研究国家重点实验室
通讯作者Mueller, Rolf
作者单位1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
3.Zhejiang Univ, Inst Marine Biol & Pharmacol, Ocean Coll, Zhoushan 316021, Peoples R China
4.Helmholtz Ctr Infect Res, Helmholtz Int Lab Antiinfect, D-38124 Braunschweig, Germany
5.Saarland Univ, Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, D-66123 Saarbrucken, Germany
推荐引用方式
GB/T 7714		 Zhao, Haowen,Ren, Yuhao,Xie, Feng,et al. Nobachelins, new siderophores from Nocardiopsis baichengensis protecting Caenorhabditis elegans from Pseudomonas aeruginosa infection[J]. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY,2023,8(4):640-646.
APA Zhao, Haowen.,Ren, Yuhao.,Xie, Feng.,Dai, Huanqin.,Liu, Hongwei.,...&Mueller, Rolf.(2023).Nobachelins, new siderophores from Nocardiopsis baichengensis protecting Caenorhabditis elegans from Pseudomonas aeruginosa infection.SYNTHETIC AND SYSTEMS BIOTECHNOLOGY,8(4),640-646.
MLA Zhao, Haowen,et al."Nobachelins, new siderophores from Nocardiopsis baichengensis protecting Caenorhabditis elegans from Pseudomonas aeruginosa infection".SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 8.4(2023):640-646.

入库方式： OAI收割

来源：上海药物研究所

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