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Oral [60]fullerene reduces neuroinflammation to alleviate Parkinson's disease via regulating gut microbiome

文献类型：期刊论文

作者Li, Xue1,5; Deng, Ruijun1,5; Li, Jie1,5; Li, Hui4; Xu, Zhe3; Zhang, Lei1; Feng, Linyin1,2; Shu, Chunying1,2,5; Zhen, Mingming1,5; Wang, Chunru1,5
刊名THERANOSTICS
出版日期2023
卷号13期号:14页码:4936-4951
ISSN号1838-7640
关键词Oral fullerene Parkinson's disease Gut microbiota Neuroinflammation Neurodegeneration
DOI10.7150/thno.85711
通讯作者Zhen, Mingming(zhenmm@iccas.ac.cn) ; Wang, Chunru(crwang@iccas.ac.cn)
英文摘要Neuroinflammation is considered to drive the pathogenic process of neuronal degeneration in Parkinson's disease (PD). However, effective anti-neuroinflammation therapeutics for PD still remain dissatisfactory. Here we explore a robust therapeutic strategy for PD using anti-neuroinflammatory fullerenes.Methods: Oral fullerene was prepared by a ball-milling method. 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP)-induced PD mouse model was used to investigate the therapeutic effects and mechanisms of it. The gut microenvironment was evaluated by 16S rRNA gene sequencing, gas chromatography-mass spectrometry, quantitative polymerase chain reaction (Q-PCR), and western blot (WB). The neuroinflammation and neurodegeneration were evaluated by pathological analysis, Elisa kits, transmission electron microscopy, Q-PCR, WB and so on. Toxicity was assessed by weight, blood test and hematoxylin-eosin (HE) staining.Results: Oral fullerene therapeutic system that dissolved [60]fullerene into olive oil (abbreviated as OFO) was dexterously designed, which could reduce neuroinflammation via regulating the diversity of gut microbiome, increasing the contents of short chain fatty acids (SCFAs) and recovering the integrity of gut barrier. Accordingly, the reduction of neuroinflammation prevented dopaminergic neuronal degeneration. And thus, OFO significantly ameliorated motor deficits and fundamentally reversed dopamine (DA) loss in MPTP-induced PD mice. Of note, OFO exhibited low toxicity towards the living body.Conclusion: Our findings suggest that OFO is a safe-to-use, easy-to-apply, and prospective candidate for PD treatment in clinic, opening a therapeutic window for neuroinflammation-triggered neurodegeneration.
WOS关键词OXIDATIVE STRESS ; CARBOXYFULLERENE ; INFLAMMATION ; MODEL ; MICROGLIA
资助项目Key Research Program of the Chinese Academy of Sciences[QYKJZD-SSW-SLH01] ; National Natural Science Foundation of China[52272048] ; Youth Innovation Promotion Association of CAS[2022036]
WOS研究方向Research & Experimental Medicine
语种英语
出版者IVYSPRING INT PUBL
WOS记录号WOS:001085028000014
源URL[http://119.78.100.183/handle/2S10ELR8/307557]  
专题中国科学院上海药物研究所
通讯作者Zhen, Mingming; Wang, Chunru
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chifeng Fullcan Biotechnol Co Ltd, Chifeng 024099, Inner Mongolia, Peoples R China
4.Beijing Fullcan Biotechnol Co Ltd, Beijing 100085, Peoples R China
5.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,,Key Lab Mol Nanostruct, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xue,Deng, Ruijun,Li, Jie,et al.
Oral [60]fullerene reduces neuroinflammation to alleviate Parkinson's disease via regulating gut microbiome[J]. THERANOSTICS,2023,13(14):4936-4951.
APA Li, Xue.,Deng, Ruijun.,Li, Jie.,Li, Hui.,Xu, Zhe.,...&Wang, Chunru.(2023).
Oral [60]fullerene reduces neuroinflammation to alleviate Parkinson's disease via regulating gut microbiome.THERANOSTICS,13(14),4936-4951.
MLA Li, Xue,et al."
Oral [60]fullerene reduces neuroinflammation to alleviate Parkinson's disease via regulating gut microbiome".THERANOSTICS 13.14(2023):4936-4951.

入库方式： OAI收割

来源：上海药物研究所

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