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Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways

文献类型：期刊论文

作者Yuan, Xiaoyan3,4,5; Yang, Junting2,4; Huang, Yuling1,4; Li, Jia1,3,4,5; Li, Yuanyuan1,3,4,5
刊名BIOMOLECULES
出版日期2023-10-01
卷号13期号:10页码:14
关键词gut-liver axis 3-Indolepropionic acid HSCs liver fibrosis
DOI10.3390/biom13101464
通讯作者Li, Jia(jli@simm.ac.cn) ; Li, Yuanyuan(liyuanyuan@simm.ac.cn)
英文摘要There has been a growing interest in studying the communication of gut microbial metabolites between the gut and the liver as liver fibrosis progresses. Although 3-Indolepropionic acid (IPA) is regarded as a clinically valuable gut metabolite for the treatment of certain chronic diseases, the effects of oral administration of IPA on hepatic fibrosis in different animal models have been conflicting. While some mechanisms have been proposed to explain these contradictory effects, the direct impact of IPA on hepatic fibrosis remains unclear. In this study, we found that IPA could directly activate LX-2 human hepatic stellate cells in vitro. IPA upregulated the expression of fibrogenic marker genes and promoted the features associated with HSCs activation, including proliferation and contractility. IPA also increased reactive oxygen species (ROS) in mitochondria and the expression of inflammation-related genes in LX-2 cells. However, when a ROS-blocking agent was used, these effects were reduced. p38 and JNK, the downstream signaling cascades of ROS, were found to be required for the activation of LX-2 induced by IPA. These findings suggest that IPA can directly activate hepatic stellate cells through ROS-induced JNK and p38 signaling pathways.
WOS关键词P38 MAPK ; STRESS
资助项目We acknowledge Yi Zang for assistance in cell culture experiment.
WOS研究方向Biochemistry & Molecular Biology
语种英语
出版者MDPI
WOS记录号WOS:001092414800001
源URL[http://119.78.100.183/handle/2S10ELR8/307563]  
专题中国科学院上海药物研究所
通讯作者Li, Jia; Li, Yuanyuan
作者单位1.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
2.Dalian Univ Technol, Sch Life & Pharmaceut Sci, Dalian 116024, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Xiaoyan,Yang, Junting,Huang, Yuling,et al. Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways[J]. BIOMOLECULES,2023,13(10):14.
APA Yuan, Xiaoyan,Yang, Junting,Huang, Yuling,Li, Jia,&Li, Yuanyuan.(2023).Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways.BIOMOLECULES,13(10),14.
MLA Yuan, Xiaoyan,et al."Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways".BIOMOLECULES 13.10(2023):14.

入库方式： OAI收割

来源：上海药物研究所

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