l -Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
文献类型：期刊论文
| 作者 | Juan Yang5; Lina Cha4; Yepeng Wang3; Quan Zhang2; Xiaopeng Tang1; Jianlin Shao5; Zilei Duan2 |
| 刊名 | NATURAL PRODUCTS AND BIOPROSPECTING
 |
| 出版日期 | 2023 |
| 卷号 | 13期号:1 |
| ISSN号 | 2192-2195 |
| 英文摘要 | l -Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are involved in the regulations of membrane molecular dynamics and the β-oxidation of fatty acids. Decreased plasma long-chain acylcarnitines showed the association of venous thrombosis, implying anticoagulant activity of the metabolites and inspiring us to investigate if and how L-PC, a long-chain acylcarnitine, takes part in coagulation. Here we show that L-PC exerted anti-coagulant effects by potentiating the enzymatic activities of plasmin and tissue plasminogen activator (tPA). L-PC directly interacts with plasmin and tPA with an equilibrium dissociation constant (KD) of 6.47?×?10 –9 and 4.46?×?10 –9 M, respectively, showing high affinities. In mouse model, L-PC administration significantly inhibited FeCl 3 -induced arterial thrombosis. It also mitigated intracerebral thrombosis and inflammation in a transient middle cerebral artery occlusion (tMCAO) mouse model. L-PC induced little bleeding complications. The results show that L-PC has anti-thrombotic function by potentiating plasmin and tPA. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307585]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.青岛大学 2.成都医学院 3.南京农业大学 4.中国科学院上海药物研究所 5.昆明医科大学 |
| 推荐引用方式 GB/T 7714 | Juan Yang,Lina Cha,Yepeng Wang,et al. l -Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis[J]. NATURAL PRODUCTS AND BIOPROSPECTING,2023,13(1). |
| APA | Juan Yang.,Lina Cha.,Yepeng Wang.,Quan Zhang.,Xiaopeng Tang.,...&Zilei Duan.(2023).l -Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis.NATURAL PRODUCTS AND BIOPROSPECTING,13(1). |
| MLA | Juan Yang,et al."l -Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis".NATURAL PRODUCTS AND BIOPROSPECTING 13.1(2023). |
入库方式： OAI收割
来源：上海药物研究所
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